Immunogenicity of soluble haemagglutinin-lipopolysaccharide complex of classical vibrio cholerae.

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dc.contributor.authorChaicumpa, Wen_US
dc.contributor.authorSwasdikosa, Sen_US
dc.date.accessioned2009-05-27T16:47:05Z
dc.date.available2009-05-27T16:47:05Z
dc.date.issued1983-12-01en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractSoluble haemagglutinin-lipopolysaccharide complexes were found to be good antigens since it elicited high levels of the antibodies in the intestine especially of the IgA class. These specific antibodies sustained for a long period of time at the significantly high levels (longer than 6 months). The enteric memory primed by the antigens in the intestinal tract were longer than 3 months. Pools of intestinal fluids obtained from mice immunized with single dose of SH-LPS at 1 week, 1 month and 3 months after the antigen stimulation conferred protection against the homologous challenge. Better protection was found in the corresponding specimens collected from mice which received antigen booster at 3 months after the first stimulation. Multiple oral doses of the antigens (three doses at weekly intervals) did not have any advantage over the single dose immunization. The intestinal fluids obtained from the former group conferred similar degree of protection as those from the latter though the serum specimens offered higher PD50. The protection against cholera does not correlate with the levels of vibriocidal antibody in the body fluids which seems to confirm the hypothesis that the mechanism of protection against cholera by intestinal antibody is by reducing or preventing the attachment of the vibrios to the epithelium either via agglutinating process or via masking of the vibrio adhesive sites.en_US
dc.identifier.citationChaicumpa W, Swasdikosa S. Immunogenicity of soluble haemagglutinin-lipopolysaccharide complex of classical vibrio cholerae. The Southeast Asian Journal of Tropical Medicine and Public Health. 1983 Dec; 14(4): 548-58en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/36003
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/publication.htmen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntibodies, Bacterial --analysisen_US
dc.subject.meshBacterial Vaccines --administration & dosageen_US
dc.subject.meshBody Fluids --immunologyen_US
dc.subject.meshEnzyme-Linked Immunosorbent Assayen_US
dc.subject.meshHemagglutinins --immunologyen_US
dc.subject.meshImmunizationen_US
dc.subject.meshImmunoglobulins --analysisen_US
dc.subject.meshImmunologic Memoryen_US
dc.subject.meshLipopolysaccharides --immunologyen_US
dc.subject.meshMiceen_US
dc.subject.meshVibrio cholerae --immunologyen_US
dc.titleImmunogenicity of soluble haemagglutinin-lipopolysaccharide complex of classical vibrio cholerae.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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