PARFLEX--a very useful drug for management of surgical pain.

Simple item page
dc.contributor.authorPant, K Ken_US
dc.contributor.authorDas, Vineetaen_US
dc.contributor.authorGrawal, S P Aen_US
dc.contributor.authorSingh, Ajayen_US
dc.contributor.authorKhattri, Sanjayen_US
dc.contributor.authorNath, Rajendraen_US
dc.contributor.authorNischal, Anuradhaen_US
dc.contributor.authorDabholkar, Pareenen_US
dc.date.accessioned2008-06-09en_US
dc.date.accessioned2009-05-31T08:03:06Z
dc.date.available2008-06-09en_US
dc.date.available2009-05-31T08:03:06Z
dc.date.issued2008-06-09en_US
dc.description.abstractThe aim was to assess and document the efficacy and tolerability of parflex (FDC of aceclofenac with paracetamol and serratiopeptidase) in management of pain and inflammation in adult patients undergoing surgical procedures (or operations). The design was open, prospective, non-comparative and multi-dose study of patients undergoing surgical procedures at a leading, tertiary-care, teaching hospital (setting) in Lucknow, the name being, King George's Medical College, Lucknow 226003. The patients were 50 adult patients of either sex undergoing surgery. They were given 1 tablet twice daily, taken after meals. Treatment duration was for a total of up to 7 days (intervention). Primary efficacy variables were relief from postoperative pain. Secondary efficacy variables were global assessment of efficacy and toleration by patients and treating physicians. Record was made of spontaneously reported adverse events with their nature, intensity and outcome (tolerability). Out of 50 patients, 31% were (ENT), 36% were (Orthopaedic) and 33% were (Gynaecology). They were enroled in this study. The observations made were mean pain score showed significant improvement with study drug - decreasing from 2.66 at baseline to 1.36 after 48 hours, and to 0.8 at the end of study. Composite score for pain, fever and swelling also showed substantial gains visit-on- visit-decreasing from 3.62 at baseline to 2.04 after 48 hours, and to 0.98 at final visit. None of the patients reported any adverse event. Global efficacy assessment was rated as 'excellent or good' by 54% of patients and in 59% of patients by their treating physicians. To conclude, parflex is an effective analgesic, anti-inflammatory drug that has a valuable therapeutic option for controlling pain and inflammation after surgical procedures.en_US
dc.description.affiliationPharmacology, King George's Medical College, Lucknow.en_US
dc.identifier.citationPant KK, Das V, Grawal SP, Singh A, Khattri S, Nath R, Nischal A, Dabholkar P. PARFLEX--a very useful drug for management of surgical pain. Journal of the Indian Medical Association. 2008 Jun; 106(6): 409-11en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/97408
dc.language.isoengen_US
dc.source.urihttps://www.jimaonline.org.in/en_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 and overen_US
dc.subject.meshAnti-Inflammatory Agents, Non-Steroidal --therapeutic useen_US
dc.subject.meshDiclofenac --analogs & derivativesen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshInflammation --drug therapyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPain, Postoperative --drug therapyen_US
dc.titlePARFLEX--a very useful drug for management of surgical pain.en_US
dc.typeJournal Articleen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Journal of the Indian Medical Association