Study of Cholesterol Levels in Ascitic Fluid to Differentiate Malignant from Non-Malignant Effusion.

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dc.contributor.authorSharma, Vinayen_US
dc.contributor.authorSharma, Rachnaen_US
dc.contributor.authorArora, Poojaen_US
dc.contributor.authorGoyal, Neetuen_US
dc.contributor.authorSharma, Sushilen_US
dc.date.accessioned2020-11-18T10:18:25Z
dc.date.available2020-11-18T10:18:25Z
dc.date.issued2020-06
dc.description.abstractCollection of more than normal quantity fluid in a serous cavity is called effusion. Itis classified as per location i.e. pericardial, pleural and peritoneal. Fluid collection inabdominal cavity is called ascites. Effusions are of two types - (1) Transudate (2)Exudate. Transudate develops as a result of physiological disturbances of circulationusually a rise in venous pressure or decrease in oncotic pressure, while exudateforms as a result of increased capillary permeability which is usually due toinflammation. Transudates usually have low specific gravity due to low proteincontent whereas exudates have high specific gravity due to high protein content.Transudates are usually associated with cardiac-, hepatic- or renal-disease. Whileexudates are caused by inflammatory conditions like tuberculosis and malignanciesof pelvic and abdominal organs. Recently fibronectin and cholesterol levels ofperitoneal fluid have been found to differentiate between ascites of differentaetiologies. The estimation of fibronectin levels in fluid is sensitive but complicated.So, in this study we have taken the value of cholesterol for the aetiologic diagnosisof ascites as a simple procedure.METHODSThe present descriptive study of 100 cases of ascites was conducted over a period of12 months i.e. January. 2019 to January 2020. Various fluids were collected fromOPD and IPD of Medical and Surgery units.RESULTSIn the present study, 84% of the cases were transudates while exudates accountedfor 16% of cases. Cirrhosis (65%) was the commonest cause among transudates.Other causes included congestive cardiac failure (09%), nephrotic syndrome (06%),& anaemias (04%). Exudative ascites was caused by tuberculosis in 10% cases &malignancy in 06% cases. Cholesterol level of >70 mg/dL was found in 82% ofmalignant ascites. So, it was concluded that ascitic fluid cholesterol levels weresignificantly greater in malignant cases in comparison to ascites caused by non -malignant aetiologies. Inference - Cholesterol concentration in ascitic fluid helps todifferentiate ascites in malignancy, from non - malignant ascites.CONCLUSIONSCholesterol estimation in ascitic fluid is a better parameter to differentiatemalignant ascites from non - malignant ascites.en_US
dc.identifier.affiliationsDepartment of Pathology, Venkateshwara Institute of Medical Sciences, Gajraula, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, SMMH Medical College, Saharanpur, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, SMMH Medical College, Saharanpur, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, SMMH Medical College, Saharanpur, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Physiology, Venkateshwara Institute of Medical Sciences, Gajraula, Uttar Pradesh, India.en_US
dc.identifier.citationSharma Vinay, Sharma Rachna, Arora Pooja, Goyal Neetu, Sharma Sushil. Study of Cholesterol Levels in Ascitic Fluid to Differentiate Malignant from Non-Malignant Effusion.. Journal of Evolution of Medical and Dental Sciences. 2020 Jun; 9(26): 1903-1907en_US
dc.identifier.issn2278-4802
dc.identifier.issn2278-4748
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/214987
dc.languageenen_US
dc.publisherAkshantala Enterprises Private Limiteden_US
dc.relation.issuenumber26en_US
dc.relation.volume9en_US
dc.source.urihttps://dx.doi.org//10.14260/jemds/2020/414en_US
dc.subjectCholesterolen_US
dc.subjectAscitesen_US
dc.subjectTransudateen_US
dc.subjectExudateen_US
dc.titleStudy of Cholesterol Levels in Ascitic Fluid to Differentiate Malignant from Non-Malignant Effusion.en_US
dc.typeJournal Articleen_US
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