A combination of intravenous immunoglobulin and pulse methylprednisolone extended survival in pulmonary alveolar proteinosis with chronic interstitial pneumonitis: a case report.

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dc.contributor.authorJirarattanasopa, Nongnapa
dc.contributor.authorTantikul, Chutsumarn
dc.contributor.authorVichyanond, Pakit
dc.contributor.authorPacharn, Punchama
dc.contributor.authorVisitsunthorn, Nualanong
dc.contributor.authorSuttinont, Panthep
dc.contributor.authorJirapongsananuruk, Orathai
dc.date.accessioned2012-01-11T05:12:11Z
dc.date.available2012-01-11T05:12:11Z
dc.date.issued2010-06
dc.description.abstractPulmonary alveolar proteinosis (PAP) is characterized by intra-alveolar accumulation of lipoproteinaceous material. The severe chronic pulmonary disease and susceptibility to pulmonary infection is a prominent feature of the disease. We reported a case of postnatal-onset PAP and chronic interstitial pneumonitis in a girl with chronic respiratory distress since she was 5 months of age. A lung biopsy confirmed the diagnosis. The therapeutic bronchoalveolar lavages, a short trial of granulocyte colony-stimulation factor (G-CSF) and a combination of low dose methylprednisolone and hydroxychloroquine were used at different times without noting satisfactory improvement. Intravenous immunoglobulin (IVIG) and pulse methylprednisolone were given monthly with gradual recovery. She did not require oxygen supplement after 21 months of this combination. Our report suggested that IVIG and pulse methylprednisolone might have a potential role in the treatment of PAP with chronic interstitial pneumonitis.en_US
dc.identifier.citationJirarattanasopa Nongnapa, Tantikul Chutsumarn, Vichyanond Pakit, Pacharn Punchama, Visitsunthorn Nualanong, Suttinont Panthep, Jirapongsananuruk Orathai. A combination of intravenous immunoglobulin and pulse methylprednisolone extended survival in pulmonary alveolar proteinosis with chronic interstitial pneumonitis: a case report. Asian Pacific Journal of Allergy and Immunology, 2010 Jun; 28(2-3): 200-205.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/136375
dc.language.isoenen_US
dc.source.urihttps://apjai.digitaljournals.org/index.php/apjai/article/viewFile/128/134en_US
dc.subjectchronic interstitial pneumonitisen_US
dc.subjectintravenous immunoglobulinen_US
dc.subjectpulmonary alveolar proteinosisen_US
dc.subjectpulse methylprednisoloneen_US
dc.titleA combination of intravenous immunoglobulin and pulse methylprednisolone extended survival in pulmonary alveolar proteinosis with chronic interstitial pneumonitis: a case report.en_US
dc.typeArticleen_US
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