Emergence of multidrug-resistant Salmonella Gloucester and Salmonella typhimurium in Bangladesh.

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dc.contributor.authorRahman, Men_US
dc.contributor.authorIslam, Hen_US
dc.contributor.authorAhmed, Den_US
dc.contributor.authorSack, R Ben_US
dc.date.accessioned2001-09-05en_US
dc.date.accessioned2009-05-27T03:49:54Z
dc.date.available2001-09-05en_US
dc.date.available2009-05-27T03:49:54Z
dc.date.issued2001-09-05en_US
dc.descriptionJournal of Health, Population, and Nutrition.en_US
dc.description.abstractInfections due to non-typhoid Salmonella, resistant to antibiotics, have recently emerged as an important health problem worldwide. Antibiotic resistance was studied by the disc-diffusion method among 3,876 (2.78%) non-typhoid Salmonella isolates cultured from 139,279 faecal samples in a diarrhoea treatment centre in Dhaka, Bangladesh, during 1989-1996. Of 499 salmonellae isolated in 1989, serogroup C (1.12%) was the most common, followed by Salmonella Typhi (0.72%) and serogroup B (0.71%). Isolation rate of serogroup B increased significantly to 2.18% (p < 0.01) in 1992 compared to 0.56% in 1991, 2.86% in 1995, and 2.48% in 1996. Serotyping of 194 serogroup B isolates revealed Salmonella Typhimurium (52%) and Salmonella Gloucester (45%) as predominant serotypes. Resistance to ampicillin (A), chloramphenicol (C), and trimethoprim-sulphamethoxazole (Sxt) (R type-ACSxt) increased to 89-100% during 1992-1996 from 20-28% during 1989-1991 (p < 0.01) among S. Typhimurium and S. Gloucester isolates. In 1993, 8-10% of the strains of both the serotypes, resistant to ampicillin, chloramphenicol, and trimethoprim-sulphamethoxazole, acquired resistance to ceftriaxone (Cr) (R type-ACSxtCr), which increased to 85-92% in 1996 (p < 0.01). All were susceptible to ciprofloxacin. A 157-kb conjugative plasmid transferred R type-ACSxt from both the serotypes to Escherichia coli K-12. The findings of the study suggest the emergence of multidrug-resistant S. Gloucester and S. Typhimurium for the first time as a significant health problem in Bangladesh, and surveillance is essential to monitor the resistant non-typhoid Salmonella and identify its sources and modes of transmission.en_US
dc.description.affiliationLaboratory Sciences Division, ICDDR,B: Centre for Health and Population Research, GPO Box 128, Dhaka 1000, Bangladesh. mahbubur@icddrb.orgen_US
dc.identifier.citationRahman M, Islam H, Ahmed D, Sack RB. Emergence of multidrug-resistant Salmonella Gloucester and Salmonella typhimurium in Bangladesh. Journal of Health, Population, and Nutrition. 2001 Sep; 19(3): 191-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/757
dc.language.isoengen_US
dc.source.urihttps://www.icddrb.org/pub/publication.jsp?classificationID=30&typeClassificationID=2en_US
dc.source.urihttps://www.icddrb.org/publication.cfm?classificationID=30&pubID=327en_US
dc.subject.meshAnti-Bacterial Agents --pharmacologyen_US
dc.subject.meshBangladesh --epidemiologyen_US
dc.subject.meshCommunicable Diseases, Emerging --drug therapyen_US
dc.subject.meshDrug Resistance, Multiple, Bacterialen_US
dc.subject.meshFeces --microbiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMicrobial Sensitivity Testsen_US
dc.subject.meshSalmonella --drug effectsen_US
dc.subject.meshSalmonella Infections --drug therapyen_US
dc.subject.meshSalmonella typhimurium --drug effectsen_US
dc.titleEmergence of multidrug-resistant Salmonella Gloucester and Salmonella typhimurium in Bangladesh.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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