Effects of dexamethasone on lipid metabolism in rat organs.

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dc.contributor.authorKaur, Nen_US
dc.contributor.authorSharma, Nen_US
dc.contributor.authorGupta, A Ken_US
dc.date.accessioned1989-12-01en_US
dc.date.accessioned2009-05-27T09:25:49Z
dc.date.available1989-12-01en_US
dc.date.available2009-05-27T09:25:49Z
dc.date.issued1989-12-01en_US
dc.description.abstractInjecting of dexamethasone (10 mg/kg body weight) for 8 days to rats decreased the body weight and feed intake by 29 and 50%, respectively. The increase in weights of liver, heart, kidneys and testes per 100 g body weight was 55, 37, 33 and 13%, respectively. Though, in general, the triglyceride content increased in all the organs, maximum increase (9-fold) was observed in the liver. The plasma showed elevated levels of triglycerides, cholesterol and phospholipids. In hepatic mitochondrial membranes, the content of protein, phospholipids and cholesterol decreased/g tissue. The percent 14C distribution, as a part of total incorporation in nonpolar lipids, of [14C]acetate into triglycerides of liver, kidneys and testes increased significantly. The increased turnover of phospholipids in liver and heart was mainly due to increased turnover of phosphatidyl choline (PC) and phosphatidyl ethanolamine in liver and PC in heart. Turnover of phospholipids of testes was not affected.en_US
dc.identifier.citationKaur N, Sharma N, Gupta AK. Effects of dexamethasone on lipid metabolism in rat organs. Indian Journal of Biochemistry & Biophysics. 1989 Dec; 26(6): 371-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/27482
dc.language.isoengen_US
dc.source.urihttps://https://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijbb/ijbb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCholesterol --metabolismen_US
dc.subject.meshDexamethasone --pharmacologyen_US
dc.subject.meshKidney --metabolismen_US
dc.subject.meshLipid Metabolismen_US
dc.subject.meshLiver --metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshMyocardium --metabolismen_US
dc.subject.meshPhospholipids --metabolismen_US
dc.subject.meshRatsen_US
dc.subject.meshTestis --metabolismen_US
dc.subject.meshTriglycerides --metabolismen_US
dc.titleEffects of dexamethasone on lipid metabolism in rat organs.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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