Renal function in late survivors of Iranian children with cancer: single centre experience.

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dc.contributor.authorArjmandi-Rafsanjani, Ken_US
dc.contributor.authorHooman, Nen_US
dc.contributor.authorVosoug, Pen_US
dc.date.accessioned2009-05-28T06:35:50Z
dc.date.available2009-05-28T06:35:50Z
dc.date.issued2008-10-30en_US
dc.description.abstractCONTEXT: One of the side-effects of chemotherapy is nephrotoxicity, whose incidence rate has reportedly been higher in pediatrics. Early diagnosis of renal dysfunction may decrease the morbidity in those with partial or complete remission by avoiding nephrotoxic agents and promoting regular follow-up. AIMS: We studied the frequency of renal dysfunction in pediatric patients whose therapy was completed regardless of the type of chemotherapy. SETTINGS AND DESIGN: Prospective cross sectional study in Hematoncology department of children's hospital. MATERIALS AND METHODS:0 One hundred and eight pediatric cancer patients (44 females, 64 males), who were at least one year off therapy, enrolled in the study from 2003 to 2005. Demographic data, mean dosages of anticancer drugs, history of other nephrotoxic agents, nephrectomy, radiotherapy and acute renal failure were recorded. Fasting blood and urine samples were collected to calculate fractional excretion of magnesium, calcium, phosphate, urine protein to urine creatinine ratio, creatinine clearance (using Schwartz formula), urine analysis, urine osmolality and blood gas analysis. Statistical analysis used: T-test, Chi square and binary logistic regression were used to compare means, frequency and correlation respectively. P values RESULTS: Renal dysfunction was seen in 25.2% of cases. These abnormalities included hypercalciuria (7.2%), phosphaturia (13.5%), magnesuria (3.6%), glomerular filtration rate less than 90 ml/min (7.5%), metabolic acidosis (3%), metabolic alkalosis (10%), urinary concentration defect (19%), proteinuria (7.2%), glycosuria (2%), microscopic hematuria (4%), sterile pyuria (6%), and hypertension (8%). We found only Procarbazin as an independent variable of nephrotoxicity (P< 0.05). CONCLUSIONS: Mild to moderate tubular dysfunction has been observed in the survivors of cancer disease.en_US
dc.description.affiliationDepartment of Pediatric Nephrology, Ali Asgar Children's Hospital, Iran University of Medical Sciences, Tehran, Iran.en_US
dc.identifier.citationArjmandi-Rafsanjani K, Hooman N, Vosoug P. Renal function in late survivors of Iranian children with cancer: single centre experience. Indian Journal of Cancer. 2008 Oct-Dec; 45(4): 154-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/50083
dc.language.isoengen_US
dc.source.urihttps://www.indianjcancer.comen_US
dc.subject.meshAdolescenten_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshCross-Sectional Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshGlomerular Filtration Rateen_US
dc.subject.meshHumansen_US
dc.subject.meshInfanten_US
dc.subject.meshIranen_US
dc.subject.meshKidney Diseases --physiopathologyen_US
dc.subject.meshKidney Function Testsen_US
dc.subject.meshKidney Tubules --physiopathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshNeoplasms --physiopathologyen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshSurvivorsen_US
dc.titleRenal function in late survivors of Iranian children with cancer: single centre experience.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
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