A study of the spectrum of Acanthamoeba keratitis: a three-year study at a tertiary eye care referral center in South India.
dc.contributor.author | Bharathi, Jayahar M | en_US |
dc.contributor.author | Srinivasan, M | en_US |
dc.contributor.author | Ramakrishnan, R | en_US |
dc.contributor.author | Meenakshi, R | en_US |
dc.contributor.author | Padmavathy, S | en_US |
dc.contributor.author | Lalitha, Prajna N | en_US |
dc.date.accessioned | 2007-01-27 | en_US |
dc.date.accessioned | 2009-05-29T09:16:34Z | |
dc.date.available | 2007-01-27 | en_US |
dc.date.available | 2009-05-29T09:16:34Z | |
dc.date.issued | 2007-01-27 | en_US |
dc.description.abstract | PURPOSE: To determine the epidemiological and clinical characteristics of Acanthamoeba keratitis and also to determine the sensitivity and specificity of smears in the detection of Acanthamoeba. MATERIALS AND METHODS: A retrospective review of all culture-positive cases of Acanthamoeba keratitis seen between October 1999 and August 2002 was performed. Corneal scrapes were subjected to culture and microscopy using standard protocols. RESULTS: Out of 3183 consecutive patients with clinically diagnosed corneal ulcers evaluated, 33 (1.04%) were found to be due to Acanthamoeba. Twenty-four out of 33 (72.72%) were less than 51 years of age (P<0.001). All patients were from rural areas (P<0.001) and 26 (78.79%) of them were agricultural workers (P=0.031). All 33 had history of corneal injury (P<0.001) and 28 (84.85%) patients had injury with mud (P<0.001). All 33 (100%) patients had previous medical treatment (P=0.009) and 10 (30.3%) had used traditional eye medicines (P=0.183). A clinical pattern of ring infiltrate was characteristic in 15 (45.45%) patients. The diameter of the corneal ulcer was more than 6 mm in 27 (81.82%) eyes (P<0.001). Twenty-six (78.79%) patients had visual acuity of perception of light on initial presentation (P<0.001) and 24 (72.73%) had the same as their final visual outcome. The sensitivity of 10% potassium hydroxide (KOH) preparation was found to be higher (P<0.001) in the detection of Acanthamoeba cysts. CONCLUSION: The incidence of Acanthamoeba keratitis amongst the corneal ulcer patients was 1% in this setting and it was mainly due to corneal injury by mud. The KOH preparation is a sensitive diagnostic tool for the detection of Acanthamoeba. Delayed diagnosis or misdiagnosis and inappropriate antimicrobial therapy results in poor visual outcome. | en_US |
dc.description.affiliation | Microbiology Research Centre, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Tirunelveli, Tamil Nadu-627 001, India. jayahar@tvl.aravind.org | en_US |
dc.identifier.citation | Bharathi JM, Srinivasan M, Ramakrishnan R, Meenakshi R, Padmavathy S, Lalitha PN. A study of the spectrum of Acanthamoeba keratitis: a three-year study at a tertiary eye care referral center in South India. Indian Journal of Ophthalmology. 2007 Jan-Feb; 55(1): 37-42 | en_US |
dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/71415 | |
dc.language.iso | eng | en_US |
dc.source.uri | https://www.ijo.in | en_US |
dc.subject.mesh | Acanthamoeba Keratitis --complications | en_US |
dc.subject.mesh | Corneal Ulcer --etiology | en_US |
dc.subject.mesh | Eye Injuries --complications | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Hydroxides --therapeutic use | en_US |
dc.subject.mesh | Incidence | en_US |
dc.subject.mesh | India --epidemiology | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Middle Aged | en_US |
dc.subject.mesh | Potassium Compounds --therapeutic use | en_US |
dc.subject.mesh | Retrospective Studies | en_US |
dc.subject.mesh | Sensitivity and Specificity | en_US |
dc.subject.mesh | Soil | en_US |
dc.title | A study of the spectrum of Acanthamoeba keratitis: a three-year study at a tertiary eye care referral center in South India. | en_US |
dc.type | Journal Article | en_US |
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