Intrarenal hemodynamic abnormality in severe form of glomerulonephritis: therapeutic benefit with vasodilators.

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dc.contributor.authorFutrakul, Pen_US
dc.contributor.authorPochanugool, Cen_US
dc.contributor.authorPoshyachinda, Men_US
dc.contributor.authorThamaree, Sen_US
dc.contributor.authorYenrudi, Sen_US
dc.contributor.authorBuranasiri, Ken_US
dc.contributor.authorSaleekul, Pen_US
dc.contributor.authorWatana, Den_US
dc.contributor.authorSensirivatana, Ren_US
dc.contributor.authorKingwatanakul, Pen_US
dc.date.accessioned2009-05-27T18:56:33Z
dc.date.available2009-05-27T18:56:33Z
dc.date.issued1992-07-01en_US
dc.descriptionChotmaihet Thangphaet. 100 references.en_US
dc.description.abstractIntrarenal hemodynamic and tubular function has been assessed in 16 patients who presented clinically with hypertension, hematuria and severe renal functional impairment. Twelve of these 16 patients had histopathologic classification as DPGN (3 cases), MPGN (3 cases) and FSGS (6 cases). The initial assessment of intrarenal hemodynamics in 11 patients revealed strikingly increased afferent (RA) and efferent arterioles (RE), filtration fraction (FF), intraglomerular capillary hydrostatic pressure (PG), whereas, there was marked reduction in renal plasma flow (RPF), in ultrafiltration coefficient (KFG) and in glomerular filtration rate (GFR). Tubular transporting defect as being reflected by enhanced fractional excretions of solutes was also observed. Both enhanced TXB2 production and diminished PGI2 may be in part responsible for the marked reduction of RPF and elevated intrarenal resistance. In light of the preceding intrarenal hemodynamics alteration, therapeutic intervention with vasodilators consisting of dipyridamole, calcium channel blocker and angiotensin convertase inhibitor has been accomplished with clinical improvement in glomerular and tubular functions following the improvement in intrarenal hemodynamics. Thus, this abnormal intrarenal hemodynamics renders a supportive view of the hemodynamically mediated glomerulo-tubulo-interstitial injury to be central to the pathogenetic mechanism.en_US
dc.description.affiliationFaculty of Medicine, Chulalongkorn University, Bangkok, Thailand.en_US
dc.identifier.citationFutrakul P, Pochanugool C, Poshyachinda M, Thamaree S, Yenrudi S, Buranasiri K, Saleekul P, Watana D, Sensirivatana R, Kingwatanakul P. Intrarenal hemodynamic abnormality in severe form of glomerulonephritis: therapeutic benefit with vasodilators. Journal of the Medical Association of Thailand. 1992 Jul; 75(7): 375-85en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/40158
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshFemaleen_US
dc.subject.meshGlomerulonephritis --drug therapyen_US
dc.subject.meshGlomerulonephritis, Membranoproliferative --drug therapyen_US
dc.subject.meshGlomerulosclerosis, Focal Segmental --drug therapyen_US
dc.subject.meshHemodynamics --drug effectsen_US
dc.subject.meshHumansen_US
dc.subject.meshKidney --physiopathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshRenal Circulation --drug effectsen_US
dc.subject.meshVasodilator Agents --therapeutic useen_US
dc.titleIntrarenal hemodynamic abnormality in severe form of glomerulonephritis: therapeutic benefit with vasodilators.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
dc.typeReviewen_US
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