Antioxidant Effects of Vitamin C on Some Hematological Parameters of Male Wistar Rats Exposed to Lead Acetate

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dc.contributor.authorOjeka, S.Oen_US
dc.contributor.authorUkoro, Blessingen_US
dc.contributor.authorOnwoke, Ebebi Elizahen_US
dc.date.accessioned2025-05-09T06:23:07Z
dc.date.available2025-05-09T06:23:07Z
dc.date.issued2024-06
dc.description.abstractThe study investigated the effects of vitamin C on platelet parameters, white blood cell count and white blood cells differentials in Wistar rats exposed to lead acetate. A total of twenty-four male Wistar rats weighing between 160g and 200g were utilized. The experimental animals were divided into four groups of six rats each (n=6). Group 1 served as the control group (received normal feed and water), group II received 10mg/kg body weight of lead acetate, group III received 100mg/kg body weight of Vitamin C, and group IV received 10mg/kg body weight of lead acetate followed by 100mg/kg body weight of Vitamin C. Lead and Vitamin C, along with normal feed, were administered for four weeks. Blood samples were collected via jugular puncture and stored in EDTA bottles for analysis to determine the blood profile of the rats. The results showed significant increase in Platelet Count (PLT) in group III and a significant decrease in Mean Platelet Volume (MPV) in group IV (Pb + vitamin C). The Mean Platelet Width (MPW) showed decrease in groups 2, 3, and 4 compared to the control group, although this decrease was not statistically significant. The study also noted an elevated level of white blood cells (WBC) in response to the antioxidant treatment, indicating a potential positive impact on immune function. In conclusion, this study demonstrates the therapeutic effect of Vitamin C against the toxic effects of lead on platelet parameters and white blood cell count and differentials.en_US
dc.identifier.affiliationsDepartment of Human Physiology, Faculty of Basic Medical Sciences, College of Health Sciences University of Port Harcourt, Port Harcourt, Choba, Rivers State, Nigeriaen_US
dc.identifier.affiliationsDepartment of Human Physiology, Faculty of Basic Medical Sciences, College of Health Sciences University of Port Harcourt, Port Harcourt, Choba, Rivers State, Nigeriaen_US
dc.identifier.affiliationsDepartment of Medical Physics, Faculty of Basic Medical Sciences, Federal University of Medical Sciences, Otukpo, Benue State, Nigeria.en_US
dc.identifier.citationOjeka S.O, Ukoro Blessing, Onwoke Ebebi Elizah . Antioxidant Effects of Vitamin C on Some Hematological Parameters of Male Wistar Rats Exposed to Lead Acetate . International Blood Research & Reviews. 2024 Jun; 15(2): 10-21en_US
dc.identifier.issn2321-7219
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/242682
dc.languageenen_US
dc.publisherMs. M. B. Mondalen_US
dc.relation.issuenumber2en_US
dc.relation.volume15en_US
dc.source.urihttps://doi.org/10.9734/ibrr/2024/v15i2335en_US
dc.subjectBlood cell counten_US
dc.subjectplateleten_US
dc.subjectthrombocytopeniaen_US
dc.subjecthuman healthen_US
dc.titleAntioxidant Effects of Vitamin C on Some Hematological Parameters of Male Wistar Rats Exposed to Lead Acetateen_US
dc.typeJournal Articleen_US
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