Recombination in human leukocyte antigen region in two Asian Indian families.
dc.contributor.author | Mishra, Mahendra N | |
dc.contributor.author | Sharma, Ajay | |
dc.date.accessioned | 2012-07-12T05:46:01Z | |
dc.date.available | 2012-07-12T05:46:01Z | |
dc.date.issued | 2012-01 | |
dc.description.abstract | BACKGROUND: Recombination (crossing over) may generate novel haplotypes that can be beneficial to a population against recently introduced pathogens. It may lead to the generation of new alleles. SETTINGS AND DESIGN: A prospective study at a tertiary care centre. AIM: To report two rare cases of crossing over in HLA region. MATERIALS AND METHODS: Tissue-typing was done by sequence specific primers (SSP) for DR locus and by both SSP and serology for Class I which was reconfirmed on fresh samples. RESULTS: In one patient crossing over had taken place in the region of A locus resulting in inheritance of A*01 instead of expected A*11. In second family crossing over had taken place in region of DRB1 locus and the sibling inherited DRB1*08 instead of DRB1*10. CONCLUSIONS: Possibility of recombination must be considered when interpreting implausible tissue-typing results of families worked up for BMT. | en_US |
dc.identifier.citation | Mishra Mahendra N, Sharma Ajay. Recombination in human leukocyte antigen region in two Asian Indian families. Indian Journal of Human Genetics. 2012 Jan; 18(1): 109-111. | en_US |
dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/139454 | |
dc.language.iso | en | en_US |
dc.source.uri | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3385164/ | en_US |
dc.subject | AML | en_US |
dc.subject | human leukocyte antigen | en_US |
dc.subject | recombination | en_US |
dc.subject | sequence specific primers | en_US |
dc.subject.mesh | Asian Continental Ancestry Group --genetics | |
dc.subject.mesh | Family | |
dc.subject.mesh | Histocompatibility Antigens | |
dc.subject.mesh | HLA Antigens --genetics | |
dc.subject.mesh | Family | |
dc.subject.mesh | HLA Antigens --genetics | |
dc.subject.mesh | Histocompatibility Antigens | |
dc.subject.mesh | Humans | |
dc.subject.mesh | India | |
dc.subject.mesh | Major Histocompatibility Complex | |
dc.subject.mesh | Recombination, Genetic | |
dc.title | Recombination in human leukocyte antigen region in two Asian Indian families. | en_US |
dc.type | Article | en_US |
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