Recombination in human leukocyte antigen region in two Asian Indian families.

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dc.contributor.authorMishra, Mahendra N
dc.contributor.authorSharma, Ajay
dc.date.accessioned2012-07-12T05:46:01Z
dc.date.available2012-07-12T05:46:01Z
dc.date.issued2012-01
dc.description.abstractBACKGROUND: Recombination (crossing over) may generate novel haplotypes that can be beneficial to a population against recently introduced pathogens. It may lead to the generation of new alleles. SETTINGS AND DESIGN: A prospective study at a tertiary care centre. AIM: To report two rare cases of crossing over in HLA region. MATERIALS AND METHODS: Tissue-typing was done by sequence specific primers (SSP) for DR locus and by both SSP and serology for Class I which was reconfirmed on fresh samples. RESULTS: In one patient crossing over had taken place in the region of A locus resulting in inheritance of A*01 instead of expected A*11. In second family crossing over had taken place in region of DRB1 locus and the sibling inherited DRB1*08 instead of DRB1*10. CONCLUSIONS: Possibility of recombination must be considered when interpreting implausible tissue-typing results of families worked up for BMT.en_US
dc.identifier.citationMishra Mahendra N, Sharma Ajay. Recombination in human leukocyte antigen region in two Asian Indian families. Indian Journal of Human Genetics. 2012 Jan; 18(1): 109-111.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/139454
dc.language.isoenen_US
dc.source.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3385164/en_US
dc.subjectAMLen_US
dc.subjecthuman leukocyte antigenen_US
dc.subjectrecombinationen_US
dc.subjectsequence specific primersen_US
dc.subject.meshAsian Continental Ancestry Group --genetics
dc.subject.meshFamily
dc.subject.meshHistocompatibility Antigens
dc.subject.meshHLA Antigens --genetics
dc.subject.meshFamily
dc.subject.meshHLA Antigens --genetics
dc.subject.meshHistocompatibility Antigens
dc.subject.meshHumans
dc.subject.meshIndia
dc.subject.meshMajor Histocompatibility Complex
dc.subject.meshRecombination, Genetic
dc.titleRecombination in human leukocyte antigen region in two Asian Indian families.en_US
dc.typeArticleen_US
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