Body electrolytes in bronchopulmonary dysplasia and the effects of diuretic therapy.

dc.contributor.authorVerma, R Pen_US
dc.contributor.authorJohn, Een_US
dc.contributor.authorFornell, Len_US
dc.contributor.authorVidyasagar, Den_US
dc.date.accessioned1994-05-01en_US
dc.date.accessioned2009-05-30T10:48:53Z
dc.date.available1994-05-01en_US
dc.date.available2009-05-30T10:48:53Z
dc.date.issued1994-05-01en_US
dc.description.abstractBody electrolytes and their regulatory hormones were studied in preterm infants who suffered from bronchopulmonary dysplasia under two groups: those who were not treated with diuretics (Group II), and those who were treated with diuretics (Group III). The values were compared with a group of matched healthy controls (Group I). Lower serum Na levels, a need of higher Na intake, and higher urinary Na concentrations and urinary specific gravity were found in Group II infants. FeNa was normal and the urinary flow rate was lower than the controls. These data suggest an inability of these infants to dilute urine. Group III infants who were treated with diuretics showed higher serum Na levels and lower urinary specific gravity than Group II infants. These values, as well as water and Na intake/output ratios, were all similar to the control values. Serum aldosterone level was highest in Group II but did not reach significance. Intracellular K concentration was not different between the groups indicating an optimum total body K balance. A significant negative correlation between serum Na and aldosterone levels was found in Group II infants, which was not noted in the controls. Significant correlations were also found between FeNa and plasma aldosterone level in the BPD groups, unlike the controls. The control group of infants showed significant positive correlation between Na balance and serum Na levels. Our results suggest that inability to dilute urine appropriately might be the reason for the BPD patients to retain body water. Water restriction and diuretic therapy therefore are reasonable therapeutic approaches in such cases.en_US
dc.description.affiliationDepartment of Pediatrics, Hahnemann University Hospital, Philadelphia, PA 19102.en_US
dc.identifier.citationVerma RP, John E, Fornell L, Vidyasagar D. Body electrolytes in bronchopulmonary dysplasia and the effects of diuretic therapy. Indian Journal of Pediatrics. 1994 May-Jun; 61(3): 213-21en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/79034
dc.language.isoengen_US
dc.source.urihttps://medind.nic.in/icb/icbai.shtmlen_US
dc.subject.meshBronchopulmonary Dysplasia --drug therapyen_US
dc.subject.meshDiuretics --therapeutic useen_US
dc.subject.meshElectrolytes --metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshInfanten_US
dc.subject.meshInfant, Newbornen_US
dc.titleBody electrolytes in bronchopulmonary dysplasia and the effects of diuretic therapy.en_US
dc.typeClinical Trialen_US
dc.typeControlled Clinical Trialen_US
dc.typeJournal Articleen_US
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