Effect of passively transferred anti-poliovirus antibodies on seroconversion.

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dc.contributor.authorBavdekar, S Ben_US
dc.contributor.authorNaik, Sen_US
dc.contributor.authorNadkarni, S Sen_US
dc.contributor.authorKamat, J Ren_US
dc.contributor.authorDeshpande, J Men_US
dc.contributor.authorVaswani, L Ken_US
dc.date.accessioned1999-01-08en_US
dc.date.accessioned2009-05-30T14:23:41Z
dc.date.available1999-01-08en_US
dc.date.available2009-05-30T14:23:41Z
dc.date.issued1999-01-08en_US
dc.description.abstractA prospective study enrolling 50 mother-infant pairs was undertaken to determine the effect of maternal antibodies on poliovirus antibody titres and seroconversion rates in infants and to determine the difference in titres and seroconversion rates following three and five doses of oral poliovaccine (OPV). Cord blood samples and samples collected 4 weeks after 3rd and 5th doses of trivalent oral poliovaccine were processed for estimation of anti-poliovirus antibody titres. These were expressed as geometric mean titres (GMT). Significance was analyzed using unpaired 't' test. The relationship between maternal antibody titres and seroconversion was determined by correlation coefficient test. Post OPV5 titres were significantly higher than post OPV3 titres for type 1 and type 2 polioviruses. Seroconversion rates against type 1, 2 and 3 polioviruses were 92.9%, 100.0% and 92.9% following OPV3 and 100.0%, 100.0% and 93.2% following OPV5. The cord blood titres did not have any relation to post-OPV3 or post-OPV5 titres. Although there is significant passive transfer of poliovirus antibodies across the placenta, this does not affect titres achieved after immunization. Post-OPV5 titres against type 1 and type 2 viruses are significantly higher than post-OPV3 titres. The seroconversion rates following OPV5 are higher than those obtained post-OPV3 but this difference is not statistically significant.en_US
dc.description.affiliationDepartment of Pediatrics, Seth G.S. Medical College, Parel, Mumbai.en_US
dc.identifier.citationBavdekar SB, Naik S, Nadkarni SS, Kamat JR, Deshpande JM, Vaswani LK. Effect of passively transferred anti-poliovirus antibodies on seroconversion. Indian Journal of Pediatrics. 1999 Jan-Feb; 66(1): 45-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/82614
dc.language.isoengen_US
dc.source.urihttps://medind.nic.in/icb/icbai.shtmlen_US
dc.subject.meshAdulten_US
dc.subject.meshAntibodies --blooden_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunization, Passiveen_US
dc.subject.meshIndiaen_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshMaleen_US
dc.subject.meshMaternal-Fetal Exchangeen_US
dc.subject.meshMothersen_US
dc.subject.meshPoliomyelitis --immunologyen_US
dc.subject.meshPoliovirus Vaccine, Oral --administration & dosageen_US
dc.subject.meshPregnancyen_US
dc.subject.meshProspective Studiesen_US
dc.titleEffect of passively transferred anti-poliovirus antibodies on seroconversion.en_US
dc.typeJournal Articleen_US
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