A double-blind controlled clinical trial to assess the role of anti-histamines in the treatment of multi-bacillary leprosy.

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dc.contributor.authorThomas, Aen_US
dc.contributor.authorNagarajan, Men_US
dc.contributor.authorChandrasekaran, Ven_US
dc.contributor.authorHari, Len_US
dc.contributor.authorSomasundaram, P Ren_US
dc.contributor.authorPrabhakar, Ren_US
dc.contributor.authorKumar, Aen_US
dc.contributor.authorBhatia, V Nen_US
dc.contributor.authorRoy, R Gen_US
dc.date.accessioned1988-10-01en_US
dc.date.accessioned2009-05-28T09:52:40Z
dc.date.available1988-10-01en_US
dc.date.available2009-05-28T09:52:40Z
dc.date.issued1988-10-01en_US
dc.description.abstractA double blind controlled clinical trial to assess the role of anti-histamines as a supplement in the treatment of leprosy was conducted in multi-bacillary cases of leprosy. In all, 120 patients with lepromatous or borderline leprosy were randomly allocated to a regimen of clofazimine and dapsone for 12 months with or without a supplement of pheniramine maleate for the first 3 months. During the 12-month period, 92% of the patients who received the supplement and 86% of the patients who had not received it had moderate or marked clinical improvement. The BI values decreased from 4.1 to 3.4 and 4.2 to 3.3, respectively. The results over the 12-month period showed that the addition of the antihistamine had not enhanced the efficacy of the regimen as evidenced by clinical and bacteriological findings.en_US
dc.description.affiliationCentral Leprosy Teaching and Research Institute, Chengalpattu.en_US
dc.identifier.citationThomas A, Nagarajan M, Chandrasekaran V, Hari L, Somasundaram PR, Prabhakar R, Kumar A, Bhatia VN, Roy RG. A double-blind controlled clinical trial to assess the role of anti-histamines in the treatment of multi-bacillary leprosy. Indian Journal of Leprosy. 1988 Oct; 60(4): 499-505en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/54529
dc.language.isoengen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshClinical Trials as Topicen_US
dc.subject.meshClofazimine --administration & dosageen_US
dc.subject.meshDapsone --administration & dosageen_US
dc.subject.meshDouble-Blind Methoden_US
dc.subject.meshDrug Therapy, Combinationen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLeprostatic Agents --administration & dosageen_US
dc.subject.meshLeprosy, Lepromatous --drug therapyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPheniramine --administration & dosageen_US
dc.titleA double-blind controlled clinical trial to assess the role of anti-histamines in the treatment of multi-bacillary leprosy.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
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