Folic acid, vitamin B12 and vitamin B12 binding proteins in patients with neuroblastoma.

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dc.contributor.authorAreekul, Sen_US
dc.contributor.authorHathirat, Pen_US
dc.contributor.authorChurdchu, Ken_US
dc.date.accessioned2009-05-27T14:41:07Z
dc.date.available2009-05-27T14:41:07Z
dc.date.issued1986-06-01en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractSerum vitamin B12, serum and red cell folate and serum vitamin B12 binding proteins were determined in 18 patients with neuroblastoma, with ages ranging from 8 months to 14 years. A mean value of serum vitamin B12 level was slightly but not significantly lower than that of the normal subjects but all of them had serum vitamin B12 levels over 150 pg/ml. There was no relationship between serum vitamin B12 levels and hemoglobin, hematocrit or white cells. Transcobalamin I (TCI) was significantly increased resulting in slightly elevated UBBC and normal TBBC levels in these patients. This could be a compensatory mechanism for the low serum vitamin B12 by increasing the unsaturated vitamin B12 binding capacity of TCI. All these findings indicated that the status of vitamin B12 in patients with neuroblastoma was within the normal limits. Treatment of neuroblastoma by giving a high dose of vitamin B12 would therefore not give any direct therapeutic effect. Both serum and red cell folate concentrations were significantly lower in the group of patients. As only 2 out of 18 patients had low serum folate and none of them had red cell folate lower than the lower limit of normal subjects; therefore these patients were only in the state of negative folate balance.en_US
dc.identifier.citationAreekul S, Hathirat P, Churdchu K. Folic acid, vitamin B12 and vitamin B12 binding proteins in patients with neuroblastoma. The Southeast Asian Journal of Tropical Medicine and Public Health. 1986 Jun; 17(2): 184-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/30802
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/publication.htmen_US
dc.subject.meshAdolescenten_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshFemaleen_US
dc.subject.meshFolic Acid --blooden_US
dc.subject.meshHumansen_US
dc.subject.meshInfanten_US
dc.subject.meshMaleen_US
dc.subject.meshNeuroblastoma --blooden_US
dc.subject.meshTranscobalamins --analysisen_US
dc.subject.meshVitamin B 12 --blooden_US
dc.titleFolic acid, vitamin B12 and vitamin B12 binding proteins in patients with neuroblastoma.en_US
dc.typeJournal Articleen_US
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