The role of epigenetics in mental disorders.

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dc.contributor.authorPeedicayil, Jacoben_US
dc.date.accessioned2007-08-13en_US
dc.date.accessioned2009-05-27T06:41:15Z
dc.date.available2007-08-13en_US
dc.date.available2009-05-27T06:41:15Z
dc.date.issued2007-08-13en_US
dc.description66 references.en_US
dc.description.abstractIt is well established that the idiopathic mental disorders have a genetic basis. Yet, genetic mapping has not definitively identified any genetic mutation or polymorphism underlying these disorders. This review discusses the role of epigenetics in the pathogenesis of the idiopathic mental disorders. Epimutations and epigenetic polymorphisms are emphasized as being an interface between the genes underlying the idiopathic mental disorders and the environment. Psychosocial factors are described as important environmental factors involved in the pathogenesis of the idiopathic mental disorders, modifying the underlying genes by epigenetic mechanisms. Epigenetic strategies to identify the genes underlying the idiopathic mental disorders are described and the available molecular evidence supporting an epigenetic pathogenesis for these disorders is discussed. It also discusses the role of epigenetic factors in the pathogenesis of neuropsychiatric disorders and the relevance of the new therapeutic option, epigenetic therapy, in treating the idiopathic mental disorders and the neuropsychiatric disorders.en_US
dc.description.affiliationDepartment of Pharmacology, Christian Medical College, Vellore, India. jpeedi@cmcvellore.ac.inen_US
dc.identifier.citationPeedicayil J. The role of epigenetics in mental disorders. Indian Journal of Medical Research. 2007 Aug; 126(2): 105-11en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/17447
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshChromosome Mappingen_US
dc.subject.meshEnvironmenten_US
dc.subject.meshEpigenesis, Geneticen_US
dc.subject.meshHumansen_US
dc.subject.meshMental Disorders --geneticsen_US
dc.subject.meshStochastic Processesen_US
dc.titleThe role of epigenetics in mental disorders.en_US
dc.typeJournal Articleen_US
dc.typeReviewen_US
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