Tissue concentration, systemic distribution and toxicity of clofazimine--an autopsy study.

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dc.contributor.authorJadhav, M Ven_US
dc.contributor.authorSathe, A Gen_US
dc.contributor.authorDeore, S Sen_US
dc.contributor.authorPatil, P Gen_US
dc.contributor.authorJoshi, N Gen_US
dc.contributor.authorJoghi, N Gen_US
dc.date.accessioned2004-04-22en_US
dc.date.accessioned2009-05-29T11:36:33Z
dc.date.available2004-04-22en_US
dc.date.available2009-05-29T11:36:33Z
dc.date.issued2004-04-22en_US
dc.description.abstractThere are very few autopsy studies available on systemic distribution of clofazimine, a drug with anti-mycobacterial activity, used in multidrug therapy (MDT) regimen of leprosy and in erythema nodosum leprosum (ENL). An autopsy study was done on a 45 year old female of lepromatous leprosy (LL) on MDT and long term high dosage of clofazimine. Patient succumbed to intractable abdominal pain, diarrhoea, hypokalemia following clofazimine treatment. Autopsy study revealed yellowish brown discoloration of skin, viscera and body fluids. Chemical extraction of the drug revealed the highest concentration of the drug in jejunum (1.5mg/gm),followed by spleen (1.2mg/gm), pancreas (0.4mg/gm), adrenal (0.25mg/gm), liver (0.21mg/gm), and less than 0.2mg/gm in lung, fat, large intestine and stomach. It can be inferred from the present study that the drug is absorbed from the jejunum and gets deposited in fat, reticulo-endothelial cells (R-E cells) and hepatocytes. The drug is best demonstrated in cryostat sections and is lost partly during tissue processing and staining. The drug toxicity can be fatal as seen in the present case.en_US
dc.description.affiliationDepartment of Pathology, BJ Medical College, Pune.en_US
dc.identifier.citationJadhav MV, Sathe AG, Deore SS, Patil PG, Joshi NG, Joghi NG. Tissue concentration, systemic distribution and toxicity of clofazimine--an autopsy study. Indian Journal of Pathology & Microbiology. 2004 Apr; 47(2): 281-3en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/73700
dc.language.isoengen_US
dc.source.urihttps://www.ijpmonline.orgen_US
dc.subject.meshAutopsyen_US
dc.subject.meshClofazimine --pharmacokineticsen_US
dc.subject.meshFatal Outcomeen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLeprostatic Agents --pharmacokineticsen_US
dc.subject.meshLeprosy, Lepromatous --drug therapyen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshTissue Distributionen_US
dc.titleTissue concentration, systemic distribution and toxicity of clofazimine--an autopsy study.en_US
dc.typeCase Reportsen_US
dc.typeJournal Articleen_US
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