Comparative role of intravitreal ranibizumab versus bevacizumab in choroidal neovascular membrane in age-related macular degeneration.
Date
2011-05
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Abstract
Context:
Ranibizumab and bevacizumab are used widely for treating patients with choroidal neovascular membrane (CNVM) secondary to age-related macular degeneration (AMD).
Aims:
To determine and compare the efficacy and safety of intravitreal ranibizumab and bevacizumab in treatment of CNVM due to AMD.
Settings and Design:
Prospective comparative case series carried out in an eye institute and eye department of a hospital in Kolkata, India.
Materials and Methods:
One hundred and four eyes with CNVM due to AMD were randomized into two groups. Group A (n=54; 24 occult) received monthly intravitreal ranibizumab injections (0.5 mg in 0.05 ml) and Group B (n=50; 22 occult) received monthly bevacizumab injections (1.25 mg in 0.05 ml) for 3 consecutive months and then as per study criteria. Data analysis done using SPSS software. P-value of <0.05 was considered statistically significant.
Results:
The mean best corrected visual acuity (BCVA) in the ranibizumab group increased from 58.19 Early Treatment Diabetic Retinopathy Study (ETDRS) letters at baseline to 64 ETDRS letters at month 3 (P<0.001). In bevacizumab group mean BCVA increased from 56.80 to 61.72 ETDRS letters at month 3 (P<0.001). At the end of 18 months, there was no statistically significant difference between groups A and B with respect to change in BCVA (P=0.563) or central macular thickness (CMT; P=0.281), as measured by optical coherence tomography (Stratus OCT 3000). No significant sight-threatening complications developed.
Conclusions:
Ranibizumab and bevacizumab are equally safe and efficacious in treating CNVM due to AMD.
Description
Keywords
Ranibizumab, bevacizumab, choroidal neovascular membrane, age-related macular degeneration, intravitreal injection, central macular thickness, best corrected visual acuity
Citation
Biswas Partha, Sengupta Subhrangshu, Choudhary Ruby, Home Subhankar, Paul Ajoy, Sinha Sourav. Comparative role of intravitreal ranibizumab versus bevacizumab in choroidal neovascular membrane in age-related macular degeneration. Indian Journal of Ophthalmology. 2011 May; 59(3): 191-196.