Effect of sodium hyaluronate eye drops combined with tobramycin, dexamethasone and pranoprofen eye drops in the treatment of dry eye after phacoemulsification

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dc.contributor.authorLu, Hongweien_US
dc.contributor.authorGuan, Yongqingen_US
dc.contributor.authorSu, Yudanen_US
dc.contributor.authorNan, Naen_US
dc.contributor.authorYuan, Yazhenen_US
dc.date.accessioned2023-08-25T06:35:31Z
dc.date.available2023-08-25T06:35:31Z
dc.date.issued2022-12
dc.description.abstractPurpose: To investigate the clinical effect of sodium hyaluronate eye drops combined with tobramycin, dexamethasone, and pranoprofen eye drops in the treatment of dry eye after phacoemulsification. Methods: Medical records of 188 patients with dry eye after phacoemulsification, treated in our hospital from August 2020 to August 2021, were included and divided into groups based on the type of dry eye treatment. Patients in the control group (n = 90) were treated with tobramycin, dexamethasone, and pranoprofen eye drops. Patients in the test group (n = 98) were treated with sodium hyaluronate, tobramycin, dexamethasone, and pranoprofen eye drops. The tear secretion test (TST), film rupture time (BUT), corneal fluorescence staining (FS) score, levels of interleukin (IL)?6, and tumor necrosis factor (TNF)?? before the treatment and at 1 month follow?up, the overall total effective rate and the number of completely cured cases were compared between the two groups. Multiple linear regression was used to calculate coefficients for predicting clinical variables. Ordinal logistic regression was used to compute coefficients and odds ratios for predicting effective scores. Results: The total effective rate in the observation group (99%) was significantly higher than that in the control group (80.00%). After the treatment, the TST and BUT indexes of the observation group were higher compared to the control group, and the FS score of the observation group was lower than that of the control group. TNF?? and IL?6 levels of the observation group were lower compared to the control group. Logistic regression analysis demonstrated that the differences in the effective rate and clinical variables between the two groups remained significant after adjusting for the effect of age. Conclusion: A combination of sodium hyaluronate, tobramycin, dexamethasone, and pranoprofen eye drops for the treatment of dry eye after phacoemulsification can improve the curative effect, reduce corneal fluorescein staining and inflammatory factor index levels compared to the treatment regimen lacking sodium hyaluronate eye drops.en_US
dc.identifier.affiliationsDepartment of Ophthalmology the Fourth Hospital of Hebei Medical University, Shijiazhuang City, Hebei Province, Chinaen_US
dc.identifier.citationLu Hongwei, Guan Yongqing, Su Yudan, Nan Na, Yuan Yazhen. Effect of sodium hyaluronate eye drops combined with tobramycin, dexamethasone and pranoprofen eye drops in the treatment of dry eye after phacoemulsification. Indian Journal of Ophthalmology. 2022 Dec; 70(12): 4319-4324en_US
dc.identifier.issn1998-3689
dc.identifier.issn0301-4738
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/224741
dc.languageenen_US
dc.publisherAll India Ophthalmological Societyen_US
dc.relation.issuenumber12en_US
dc.relation.volume70en_US
dc.source.urihttps://doi.org/10.4103/ijo.IJO_1652_22en_US
dc.subjectPhacoemulsification cataract extractionen_US
dc.subjectpranoprofen eye dropsen_US
dc.subjectsodium hyaluronate eye dropsen_US
dc.subjecttobramycin dexamethasoneen_US
dc.subjectxerophthalmiaen_US
dc.titleEffect of sodium hyaluronate eye drops combined with tobramycin, dexamethasone and pranoprofen eye drops in the treatment of dry eye after phacoemulsificationen_US
dc.typeJournal Articleen_US
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