Predictors of acute kidney injury in patients undergoing adult cardiac surgery

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dc.contributor.authorGangadharan, Srejaen_US
dc.contributor.authorSundaram, KRen_US
dc.contributor.authorVasudevan, Senthilvelanen_US
dc.contributor.authorAnanthakrishnan, Ben_US
dc.contributor.authorBalachandran, Rakhien_US
dc.contributor.authorCherian, Abrahamen_US
dc.contributor.authorVarma, Praveen Keralaen_US
dc.contributor.authorGracia, Luis Bakeroen_US
dc.contributor.authorMurukan, Ken_US
dc.contributor.authorMadaiker, Ashishen_US
dc.contributor.authorJose, Rajeshen_US
dc.contributor.authorSeetharaman, Rakeshen_US
dc.contributor.authorGopal, Kirunen_US
dc.contributor.authorMenon, Sujathaen_US
dc.contributor.authorThushara, Men_US
dc.contributor.authorJose, Reshmi Lizaen_US
dc.contributor.authorDeepak, Gen_US
dc.contributor.authorVanga, Sudheer Babuen_US
dc.contributor.authorJayant, Aveeken_US
dc.date.accessioned2019-12-02T09:43:41Z
dc.date.available2019-12-02T09:43:41Z
dc.date.issued2018-10
dc.description.abstractBackground: Acute kidney injury (AKI) after cardiac surgery (CS) is not uncommon and has serious effects on mortality and morbidity. A majority of patients suffer mild forms of AKI. There is a paucity of Indian data regarding this important complication after CS. Aims and Objectives: The primary objective was to study the incidence of AKI associated with CS in an Indian study population. Secondary objectives were to describe the risk factors associated with AKI-CS in our population and to generate outcome data in patients who suffer this complication. Methods: Serial patients (n = 400) presenting for adult CS (emergency/elective) at a tertiary referral care hospital in South India from August 2016 to November 2017 were included as the study individuals. The incidence of AKI-CS AKI network (AKIN criteria), risk factors associated with this condition and the outcomes following AKI-CS are described. Results: Out of 400, 37 (9.25%) patients developed AKI after CS. AKI associated with CS was associated with a mortality of 13.5% (no AKI group mortality 2.8%, P = 0.001 [P < 0.05]). When AKI was severe enough to need renal replacement therapy, the mortality increased to 75%. Patients with AKI had a mean hospital stay 16.92 ± 12.75 days which was comparatively longer than patients without AKI (14 ± 7.98 days). Recent acute coronary syndrome, postoperative atrial fibrillation, and systemic hypertension significantly predicted the onset of AKI-CS in our population. Conclusions: The overall incidence of AKI-CS was 9.25%. The incidence of AKI-CS requiring dialysis (Stage 3 AKIN) AKI-CS was lower (2%). However, mortality risks were disproportionately high in patients with AKIN Stage 3 AKI-CS (75%). There is a need for quality improvement in the care of patients with AKI-CS in its most severe forms since mortality risks posed by the development of Stage 3 AKIN AKI is higher than reported in other index populations from high resource settings.en_US
dc.identifier.affiliationsDepartment of Cardiac Anaesthesia, Amrita Institute of Medical Sciences and Research Centre, Kochi, Kerala, Indiaen_US
dc.identifier.affiliationsDepartment of Biostatistics, Amrita Institute of Medical Sciences and Research Centre, Kochi, Kerala, Indiaen_US
dc.identifier.affiliationsDepartment of Cardiothoracic Surgery, Amrita Institute of Medical Sciences and Research Centre, Kochi, Kerala, Indiaen_US
dc.identifier.citationGangadharan Sreja, Sundaram KR, Vasudevan Senthilvelan, Ananthakrishnan B, Balachandran Rakhi, Cherian Abraham, Varma Praveen Kerala, Gracia Luis Bakero, Murukan K, Madaiker Ashish, Jose Rajesh, Seetharaman Rakesh, Gopal Kirun, Menon Sujatha, Thushara M, Jose Reshmi Liza, Deepak G, Vanga Sudheer Babu, Jayant Aveek. Predictors of acute kidney injury in patients undergoing adult cardiac surgery. Annals of Cardiac Anaesthesia. 2018 Oct; 21(4): 448-454en_US
dc.identifier.issn0971-9784
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/185774
dc.languageenen_US
dc.publisherWolters Kluwer - Medknowen_US
dc.relation.issuenumber4en_US
dc.relation.volume21en_US
dc.source.urihttps://dx.doi.org/10.4103/aca.ACA_21_18en_US
dc.subjectAcute kidney injuryen_US
dc.subjectacute kidney injury network criteriaen_US
dc.subjectcardiac surgeryen_US
dc.subjectmortalityen_US
dc.subjectrenal failure requiring dialysisen_US
dc.subjectrisk stratificationen_US
dc.titlePredictors of acute kidney injury in patients undergoing adult cardiac surgeryen_US
dc.typeJournal Articleen_US
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