Drug resistance pattern of Mycobacterium tuberculosis in seropositive and seronegative HIV-TB patients in Pune, India.

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dc.contributor.authorPereira, Mycalen_US
dc.contributor.authorTripathy, Srikanthen_US
dc.contributor.authorInamdar, Vikasen_US
dc.contributor.authorRamesh, Ken_US
dc.contributor.authorBhavsar, Manojen_US
dc.contributor.authorDate, Amrutaen_US
dc.contributor.authorIyyer, Rajshekaren_US
dc.contributor.authorAcchammachary, Ananden_US
dc.contributor.authorMehendale, Sanjayen_US
dc.contributor.authorRisbud, Arunen_US
dc.date.accessioned2005-04-09en_US
dc.date.accessioned2009-05-27T07:13:58Z
dc.date.available2005-04-09en_US
dc.date.available2009-05-27T07:13:58Z
dc.date.issued2005-04-09en_US
dc.description.abstractBACKGROUND & OBJECTIVE: Tuberculosis is the commonest opportunistic disease in persons infected with human immunodeficiency virus (HIV). Emergence of drug resistant isolates of M. tuberculosis highlights the need for continuous monitoring of drug resistance to antituberculosis drugs. Considering the reported high prevalence of drug resistance in HIV infected tuberculosis patients, we studied the anti-tuberculosis drug resistance pattern of M. tuberculosis in HIV seropositive and seronegative tuberculosis patients in Pune, Maharashtra, India. METHODS: A total of 70 M. tuberculosis isolates, 30 from HIV seropositive and 40 from HIV seronegative tuberculosis patients with no previous history of anti-tuberculosis treatment, were isolated from sputum samples on Lowenstein-Jensen (LJ) medium, confirmed by conventional biochemical tests and stored at -70 degrees C. They were revived by subculturing on LJ medium and tested for drug resistance against four first-line antitubercular drugs by BACTEC Mycobacterial growth indicator tube 960 (MGIT 960) system. RESULTS: Of the 30 isolates from HIV infected patients, 10 per cent were resistant to isoniazid (H), 6.6 per cent to streptomycin (S), 6.6 per cent to ethambutol (E) and 10 per cent were multi drug resistant (MDR). Of the 40 M. tuberculosis isolates from HIV uninfected individuals, 10 per cent were resistant to H, 2.5 per cent to S, 2.5 per cent to E, and 2.5 per cent isolates were MDR. INTERPRETATION & CONCLUSION: The prevalence of drug resistant M. tuberculosis isolates among HIV seropositive tuberculosis patients was similar to that of HIV seronegative TB patients, indicating HIV infection may not be associated with drug resistant tuberculosis. However, considering the results from other studies and a high prevalence of HIV-TB infection in the country, monitoring of drug resistance in M. tuberculosis isolates needs prioritization to ensure success in national tuberculosis control programme.en_US
dc.description.affiliationNational AIDS Research Institute (ICMR), G-73, MIDC, Bhosari, Pune 411 026, India.en_US
dc.identifier.citationPereira M, Tripathy S, Inamdar V, Ramesh K, Bhavsar M, Date A, Iyyer R, Acchammachary A, Mehendale S, Risbud A. Drug resistance pattern of Mycobacterium tuberculosis in seropositive and seronegative HIV-TB patients in Pune, India. Indian Journal of Medical Research. 2005 Apr; 121(4): 235-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/19852
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAntitubercular Agents --pharmacologyen_US
dc.subject.meshDrug Resistance, Microbialen_US
dc.subject.meshHIV Seronegativityen_US
dc.subject.meshHIV Seropositivityen_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshMycobacterium tuberculosis --drug effectsen_US
dc.subject.meshTuberculosis --microbiologyen_US
dc.titleDrug resistance pattern of Mycobacterium tuberculosis in seropositive and seronegative HIV-TB patients in Pune, India.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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