CTX-M extended-spectrum beta-lactamases among clinical isolates of Enterobacteriaceae in a Thai university hospital.

Simple item page
dc.contributor.authorChanawong, Aroonwadeeen_US
dc.contributor.authorLulitanond, Aroonlugen_US
dc.contributor.authorKaewkes, Wanlopen_US
dc.contributor.authorLulitanond, Viraphongen_US
dc.contributor.authorSrigulbutr, Sukanyaen_US
dc.contributor.authorHomchampa, Preechaen_US
dc.date.accessioned2009-05-27T14:58:05Z
dc.date.available2009-05-27T14:58:05Z
dc.date.issued2007-05-20en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractThis study presents updates on molecular epidemiology of extended-spectrum beta-lactamases (ESBLs) in clinical isolates of Enterobacteriaceae from Srinagarind Hospital, Khon Kaen University, Thailand. All isolates were screened for the presence of ESBL genes, bla(TEM), bla(SHV), bla(VEB) and bla(CTX-M), using PCR followed by nucleotide sequence determination. The results revealed that beta-lactamase genes among 48 isolates collected between 1998 and 1999 were bla(SHV) (79%), bla(CTX-M-9) (52%), bla(TEM-1) (48%) and bla(VEB) (33%), whereas those found in 52 isolates collected in 2003 were bla(TEM-1) (79%), bla(CTX-M-15) (44%), bla(SHV) (36%), bla(VEB) (36%), bla(CTX -M-14) (11%) and bla(CTX-M-9) (10%). In addition, 45 isolates carried at least two different ESBL genes. Using PCR, part of insertion sequence ISEcpl was found in the upstream regions of bla(CTX-M-14) and bla(CTX-M-15). ERIC-PCR analysis revealed that most ESBL-producing isolates were of different strains. This is the first report of CTX-M-9, CTX-M-14 and CTX-M-15 beta-lactamase genes in Enterobacteriaceae in Thailand.en_US
dc.description.affiliationFaculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand. aroonwad@kku.ac.then_US
dc.identifier.citationChanawong A, Lulitanond A, Kaewkes W, Lulitanond V, Srigulbutr S, Homchampa P. CTX-M extended-spectrum beta-lactamases among clinical isolates of Enterobacteriaceae in a Thai university hospital. The Southeast Asian Journal of Tropical Medicine and Public Health. 2007 May; 38(3): 493-500en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/31566
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/2007_38_3/14-3933.pdfen_US
dc.subject.meshAnti-Bacterial Agentsen_US
dc.subject.meshCephalosporins --therapeutic useen_US
dc.subject.meshEnterobacteriaceae --geneticsen_US
dc.subject.meshEpidemiology, Molecularen_US
dc.subject.meshGenetic Screeningen_US
dc.subject.meshHospitals, Universityen_US
dc.subject.meshHumansen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshThailanden_US
dc.subject.meshbeta-Lactamases --geneticsen_US
dc.titleCTX-M extended-spectrum beta-lactamases among clinical isolates of Enterobacteriaceae in a Thai university hospital.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
493.pdf
Size:
55.74 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Southeast Asian Journal of Tropical Medicine and Public Health