Incidence of thrombocytopenia in neonates receiving phototherapy for indirect hyperbilirubinemia: a prospective cohort study

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dc.contributor.authorShah, Mubashir H.en_US
dc.contributor.authorVedula, Ramyaen_US
dc.contributor.authorRoshan, Reashmaen_US
dc.date.accessioned2020-11-18T09:59:35Z
dc.date.available2020-11-18T09:59:35Z
dc.date.issued2019-09
dc.description.abstractBackground: Thrombocytopenia as a side effect of phototherapy has not been mentioned in the standard literature but was described briefly as isolated case reports after the phototherapy came in vogue in 1958. The purpose of this study was to find the incidence of thrombocytopenia in neonates with uncomplicated indirect hyperbilirubinemia receiving phototherapy in a referral hospital.Methods: This was a prospective cohort study conducted in a referral hospital over a period of 18 months from June 1, 2013 to November 1, 2014.Results: A total of 103 babies were enrolled. The overall incidence of post-phototherapy thrombocytopenia was 45.6% while mild, moderate and severe thrombocytopenia was present in 66%, 21.3% and 12.8% of babies respectively. The lowest platelet count observed was 31,000/mm3 but none of the neonates showed bleeding manifestations. The incidence of thrombocytopenia following phototherapy was significantly higher in preterm babies, infants who received double surface phototherapy, babies who received phototherapy for >72 hours and in babies who received phototherapy on day 2 or 3 of life.Conclusions: Neonates requiring phototherapy for hyperbilirubinemia are at risk of developing thrombocytopenia, hence the treatment should be initiated based on the standard guidelines. Unnecessary use and prolongation of phototherapy should be avoided considering the possible side effects. Platelet count should be monitored particularly in pre-term neonates receiving phototherapy. Neonates receiving double surface phototherapy and those requiring phototherapy for longer duration require more frequent platelet count monitoring.en_US
dc.identifier.affiliationsDepartment of Pediatrics & Neonatology, Motherhood Women & Children’s Hospital, Pune, Maharashtra, Indiaen_US
dc.identifier.affiliationsDepartment of Pediatric Nephrology, Omni RK Hospital, Vishakhapatnam, Andhra Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Clinical Hematology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, Indiaen_US
dc.identifier.citationShah Mubashir H., Vedula Ramya, Roshan Reashma. Incidence of thrombocytopenia in neonates receiving phototherapy for indirect hyperbilirubinemia: a prospective cohort study. International Journal of Research in Medical Sciences. 2019 Sep; 7(9): 3505-3509en_US
dc.identifier.issn2320-6071
dc.identifier.issn2320-6012
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/211727
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber9en_US
dc.relation.volume7en_US
dc.source.urihttps://dx.doi.org/10.18203/2320-6012.ijrms20193937en_US
dc.subjectHyperbilirubinemiaen_US
dc.subjectIncidenceen_US
dc.subjectNeonatesen_US
dc.subjectPhototherapyen_US
dc.subjectThrombocytopeniaen_US
dc.titleIncidence of thrombocytopenia in neonates receiving phototherapy for indirect hyperbilirubinemia: a prospective cohort studyen_US
dc.typeJournal Articleen_US
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