Etiology and clinical profile of ambiguous genitalia an overview of 10 years experience.

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dc.contributor.authorJoshi, Rajesh Ren_US
dc.contributor.authorRao, Sudhaen_US
dc.contributor.authorDesai, Mennaen_US
dc.date.accessioned2006-11-08en_US
dc.date.accessioned2009-05-27T04:59:08Z
dc.date.available2006-11-08en_US
dc.date.available2009-05-27T04:59:08Z
dc.date.issued2006-11-08en_US
dc.description.abstractOne hundred nine patients presenting with ambiguous genitalia over the past 10 years (year 1995 to 2004) to Pediatric Endocrine Service of our hospital were reviewed. On the basis of clinical and investigative evaluation like hormonal and biochemical estimations, imaging studies, karyotype and invasive techniques like genitoscopy, laproscopy, open exploration and biopsy of gonads when indicated, these cases could be categorised as Genetic females with virilisation or FPH (n = 30 cases, 27.5 % Genetic males undervirilised or MPH (n = 57 cases, 52.3 %), Disorders of gonadal differentiation (n = 11, 10.1 %) Nine patients with gonadal dysgenesis and 2 with true hermaphroditism and the syndromic form of ambiguous genitalia (n = 2, 1.8 %). Congenital adrenal hyperplasia (CAH) was the underlying cause in all cases of FPH, the salt wasting form in 23/30 and simple virilising form in 7. Major categories in MPH group were Androgen insensitivity syndrome in 28 % (16/57) and 5a reductase deficiency in 23% (13/57).en_US
dc.description.affiliationDivision of Pediatric Endocrinology, Department of Pediatrics, B J Wadia Hospital for Children, Parel, Mumbai, India. rrj23@rediffmail.comen_US
dc.identifier.citationJoshi RR, Rao S, Desai M. Etiology and clinical profile of ambiguous genitalia an overview of 10 years experience. Indian Pediatrics. 2006 Nov; 43(11): 974-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/7095
dc.language.isoengen_US
dc.source.urihttps://indianpediatrics.neten_US
dc.subject.meshAdrenal Hyperplasia, Congenital --complicationsen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshMaleen_US
dc.subject.meshPseudohermaphroditism --diagnosisen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshSex Differentiation Disorders --diagnosisen_US
dc.titleEtiology and clinical profile of ambiguous genitalia an overview of 10 years experience.en_US
dc.typeJournal Articleen_US
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