Isolation, Identification And Characterization Of Degradation Impurity Of Atorvastatin In Fixed Dose Combination Of Atorvastatin And Ezetimibe

Simple item page
dc.contributor.authorDesai, R.en_US
dc.contributor.authorKoradia, S.en_US
dc.date.accessioned2020-10-16T07:50:04Z
dc.date.available2020-10-16T07:50:04Z
dc.date.issued2019-09
dc.description.abstractThe objective of this study is to isolation and characterization of unknown degradation product of Atorvastatin calcium in combination formulation product with Ezetimibe by using modern techniques of separation and characterization. An unknown impurity is generating during a forced degradation study of Atorvastatin and Ezetimibe fixed-dose combination tablets. By using the gradient reversed-phase high-pressure liquid chromatographic method, unknown degradation impurity was detected and quantified in the range of 0.05% to 0.2% of Atorvastatin. The impurity was enriched by extreme oxidation degradation of Atorvastatin and isolated through preparative HPLC. The structure of the impurity was characterized by mass and NMR spectrum.en_US
dc.identifier.affiliationsSchool of Science, RK University, Rajkot, Gujarat, Indiaen_US
dc.identifier.affiliationsShree M. & N. Virani Science College, Rajkot, Gujarat, Indiaen_US
dc.identifier.citationDesai R., Koradia S.. Isolation, Identification And Characterization Of Degradation Impurity Of Atorvastatin In Fixed Dose Combination Of Atorvastatin And Ezetimibe. International Journal of Pharmaceutical Sciences and Drug Research. 2019 Sep; 11(5): 187-193en_US
dc.identifier.issn0975-248X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/206246
dc.languageenen_US
dc.publisherMRI Publication Pvt. Ltd.en_US
dc.relation.issuenumber5en_US
dc.relation.volume11en_US
dc.source.urihttps://doi.org/10.25004/IJPSDR.2019.110506en_US
dc.subjectAtorvastatin calciumen_US
dc.subjectEzetimibeen_US
dc.subjectHPLCen_US
dc.subjectMassen_US
dc.subjectNMRen_US
dc.subjectDegradationen_US
dc.titleIsolation, Identification And Characterization Of Degradation Impurity Of Atorvastatin In Fixed Dose Combination Of Atorvastatin And Ezetimibeen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ijpsdr2019v11n5p187.pdf
Size:
1.18 MB
Format:
Adobe Portable Document Format
Download
Collections
International Journal of Pharmaceutical Sciences and Drug Research