Intralesional Verapamil for the Treatment of Peyronie’s Disease: A Prospective Study

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dc.contributor.authorArya, Mukesh Chandraen_US
dc.contributor.authorSwami, Jai Prakashen_US
dc.contributor.authorYogendraen_US
dc.contributor.authorJadaon, Abhiyutthan Singhen_US
dc.contributor.authorHariyawat, Bheru Singhen_US
dc.contributor.authorVasudeo, Viveken_US
dc.contributor.authorGandhi, Ajayen_US
dc.contributor.authorSinghal, Ankuren_US
dc.date.accessioned2020-09-24T07:25:30Z
dc.date.available2020-09-24T07:25:30Z
dc.date.issued2019-05
dc.description.abstractBackground: Peyronie’s disease is an inflammatory, fibroticpenile disorder affecting men in age range of 19-83 years. Itoccurs as an acute or chronic phase and rarely cases resolveon their own. Several treatment options are available includingoral, intralesional and surgery. Although several clinical trialshave been performed, they lack significant and corroboratedresults hence there is a need to attempt prospective researchto elucidate the most effective therapies. The aim of this studyis to determine the efficacy of intralesional injection ofverapamil over normal saline.Methods: This was a randomized parallel group studyconducted between March 2013 and February 2017 whichrandomized patients with Peyronie’s disease into two groups toreceive verapamil or normal saline intralesional injections, withinclusion criteria of penile curvature with or without plaque.After 6 biweekly injections, all above parameters andsatisfaction score was reexamined. Patients were evaluated byhistory, physical examination, questionnaire, ultrasonographyand color Doppler study of the penis.Results: A total of 53 patients were enrolled (verapamil, n=28;control, n=25). Overall, among verapamil group attenuatedcurvature, erectile dysfunction and reduced plaque size werefound in 82%, 64.2%, 67.8% of and 60.7of patientsrespectively. Pain decreased in both groups considerable to97% and 91%. Overall satisfaction level was higher inverapamil group that is82% to control group of 40%.Conclusion: Intralesional verapamil is a good treatmentchoice with absence of invasive procedures and overall goodsuccess rate and patient acceptability.en_US
dc.identifier.affiliationsMS, M.Ch., Senior Professor & Head,Department of Urology, SP Medical College, Bikaner, Rajasthan, Indiaen_US
dc.identifier.affiliationsAssistant Professor,Department of Urology, SP Medical College, Bikaner, Rajasthan, Indiaen_US
dc.identifier.affiliationsM.Ch. Resident,Department of Urology, SP Medical College, Bikaner, Rajasthan, Indiaen_US
dc.identifier.citationArya Mukesh Chandra, Swami Jai Prakash, Yogendra, Jadaon Abhiyutthan Singh, Hariyawat Bheru Singh, Vasudeo Vivek, Gandhi Ajay, Singhal Ankur. Intralesional Verapamil for the Treatment of Peyronie’s Disease: A Prospective Study. International Journal of Medical Research Professionals. 2019 Jul; 5(3): 152-155en_US
dc.identifier.issn2454-6364
dc.identifier.issn2454-6356
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/203338
dc.languageenen_US
dc.publisherIbn Sina Academy of Medieval Medicine & Sciencesen_US
dc.relation.issuenumber3en_US
dc.relation.volume5en_US
dc.source.urihttps://dx.doi.org//10.21276/ijmrp.2019.5.3.033en_US
dc.subjectIntralesionalen_US
dc.subjectPlaqueen_US
dc.subjectPenile Curvatureen_US
dc.titleIntralesional Verapamil for the Treatment of Peyronie’s Disease: A Prospective Studyen_US
dc.typeJournal Articleen_US
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