To Study the Prevalence of Thyroid Dysfunction in Newly Diagnosed HIV +ve Patients and Correlation between CD4 Count and Thyroid Dysfunction.
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Date
2016-11
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Abstract
Background: Thyroid dysfunction is one of the common endocrine dysfunction in HIV Positive patients. Newly Diagnosed
HIV Positive patients are rarely monitored for this problem. Objective:- To study the prevalence of thyroid dysfunction in
newly diagnosed HIV positive patients & to Correlate it with CD4 Count. Methods: A prevalence study was carried out on
150 newly diagnosed HIV Positive patients with different CD4 Counts divided in three groups (Group A; CD4<350, Group
B; CD4 350-550 and Group C; CD4>550) who were evaluated for thyroid dysfunction. Blood samples were collected for
CD4 T Lymphocytes. Counts were determined by flow cytometry and Thyroid function was evaluated by
chemiluminescence immunoassay. Results: Out of 150 cases studied, 47 Patients (31.33%) had thyroid dysfunction.
Group A, B and C had Thyroid dysfunction in 40 %( 20), 32 %( 16) and 22 %( 11) patients respectively. All except one had
hypothyroid state (TSH above normal range).When the results were analyzed for 150 patients with Pearson correlation
coefficient. There was an inverse correlation of CD4 count and TSH. There was progressive decline in T3, T4 levels as
CD4 count decreased. Conclusion: Thyroid dysfunction is frequent in newly diagnosed HIV positive patients and
prevalence of thyroid dysfunction increased with decrease in CD4 count. TSH levels increased as CD4 count declined.
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Keywords
AIDS, HIV, Thyroid
Citation
Sachdeva Satish, Kaur Satinder Pal, Garg Rama, Khurana Tarvinderjit, Kathuria Heena, Singh Balkar. To Study the Prevalence of Thyroid Dysfunction in Newly Diagnosed HIV +ve Patients and Correlation between CD4 Count and Thyroid Dysfunction. Annals of International Medical and Dental Research. 2016 Nov-Dec; 2(6): 46-49.