Ligand-binding prediction for ErbB2, a key molecule in the pathogenesis of leprosy.

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dc.contributor.authorWiwanitkit, Virojen_US
dc.date.accessioned2009-05-28T08:41:22Z
dc.date.available2009-05-28T08:41:22Z
dc.date.issued2008-01-12en_US
dc.description.abstractBACKGROUND AND AIMS: Mycobacterium leprae is an obligate intracellular pathogen. Ligand-binding is an important factor in the success of chemoprevention and chemotherapy. A new drug that can inhibit M. leprae binding to and activation of, ErbB2 and Erk1/2 in primary Schwann cells is the new therapeutic option. However, the ligand-binding pattern of ErbB2 has never been clarified. METHODS: In this work, the author performed a ligand-binding prediction for ErbB2 using a new bioinformatics tool. RESULTS: According to this study, nine strong possible ligands can be identified. CONCLUSION: These sites can be useful for further drug-development studies.en_US
dc.description.affiliationDepartment of Clinical Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. wviroj@yahoo.comen_US
dc.identifier.citationWiwanitkit V. Ligand-binding prediction for ErbB2, a key molecule in the pathogenesis of leprosy. Indian Journal of Dermatology, Venereology and Leprology. 2008 Jan-Feb; 74(1): 32-4en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/52980
dc.language.isoengen_US
dc.source.urihttps://www.ijdvl.comen_US
dc.subject.meshBinding Sitesen_US
dc.subject.meshComputational Biologyen_US
dc.subject.meshDrug Designen_US
dc.subject.meshHumansen_US
dc.subject.meshLeprosy --metabolismen_US
dc.subject.meshLigandsen_US
dc.subject.meshMycobacterium leprae --metabolismen_US
dc.subject.meshPredictive Value of Testsen_US
dc.subject.meshProtein Bindingen_US
dc.subject.meshReceptor, erbB-2 --chemistryen_US
dc.subject.meshVirulenceen_US
dc.titleLigand-binding prediction for ErbB2, a key molecule in the pathogenesis of leprosy.en_US
dc.typeJournal Articleen_US
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