Clinical utility of serum human epidermal receptor-2/neu detection in breast cancer patients.

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dc.contributor.authorThriveni, Ken_US
dc.contributor.authorDeshmane, Vijayalakshmien_US
dc.contributor.authorBapsy, P Pen_US
dc.contributor.authorKrishnamoorthy, Lakshmien_US
dc.contributor.authorRamaswamy, Girijaen_US
dc.date.accessioned2007-02-14en_US
dc.date.accessioned2009-05-27T08:48:35Z
dc.date.available2007-02-14en_US
dc.date.available2009-05-27T08:48:35Z
dc.date.issued2007-02-14en_US
dc.description.abstractBACKGROUND & OBJECTIVE: In breast cancer, the HER-2/neu gene is amplified in 20-30 per cent of cases. The mechanism by which the amplification/overexpression occurs is not known. Elevated serum HER-2/neu levels have been shown to be associated with a poor clinical prognosis and decreased survival in early stage breast cancer patients, and thus might help in management of the disease. The present study was therefore to estimate the serum HER-2/neu levels in breast cancer patients and associate with other prognostic factors. METHODS: Serum HER-2/neu levels were studied in 207 patients with cancer breast, 15 benign breast diseases (BBD) and 175 age-matched healthy controls. Patients' age, menopausal status, node and hormone receptor status were compared with serum HER-2/neu levels. RESULTS: Serum HER-2/neu overexpression was associated with age, disease stage and positive nodal status but not with menopausal status. Serum HER-2/neu levels were negatively related with hormone receptor positivity. INTERPRETATION & CONCLUSION: HER-2/neu serum test could be done more frequently in women with breast cancer irrespective of the hormone receptor status, to suggest modifications in systemic adjuvant therapy, including possibly the use of Herceptin.en_US
dc.description.affiliationDepartments of Biochemistry, Kidwai Memorial Institute of Oncology, Dr. M.H. Marigowda Road, Bangalore 560029, India. trivenibhat19@yahoo.comen_US
dc.identifier.citationThriveni K, Deshmane V, Bapsy PP, Krishnamoorthy L, Ramaswamy G. Clinical utility of serum human epidermal receptor-2/neu detection in breast cancer patients. Indian Journal of Medical Research. 2007 Feb; 125(2): 137-42en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/25710
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAge Factorsen_US
dc.subject.meshBreast Neoplasms --blooden_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Expression Regulation, Neoplasticen_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshLogistic Modelsen_US
dc.subject.meshNeoplasm Staging --methodsen_US
dc.subject.meshReceptor, erbB-2 --blooden_US
dc.titleClinical utility of serum human epidermal receptor-2/neu detection in breast cancer patients.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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