Impact of Metal and Metal Oxide Nanoparticles on Male Reproductive System: A Comprehensive Review

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dc.contributor.authorRajamani, Paulrajen_US
dc.contributor.authorM P, Ajithen_US
dc.contributor.authorGautam, Rohiten_US
dc.date.accessioned2023-08-09T06:02:03Z
dc.date.available2023-08-09T06:02:03Z
dc.date.issued2022-11
dc.description.abstractTechnological advancements and increased use of chemically hazardous materials have become a concern for human health. Environmental pollutants such as engineered metal and metal oxide nanoparticles (M&MONPs) are reported to contribute to significant health-related problems, particularly reproductive health. Reduction in male individuals' reproductive potential is one of the important causes of concern. Literature suggests that exposure to M&MONPs considerably impacts alteration in male reproductive parameters. Therefore, it is required to analyze and understand their effects on male reproductive toxicity. Oxidative stress and changes in redox equilibrium are the significant factors via M&MONPs induce changes in sperm parameters or the reproductive system. Act as endocrine disruptors and interfere with the secretion and function of reproductive hormones such as testosterone and LH, affecting spermatogenesis. Likewise, M&MONPs accumulate in organs as they can pass through the blood-testis barrier, affect Sertoli and Leydig cells, and cause reproductive dysfunction. In this review, we have analyzed the effects of M&MONPs on the male reproductive system and the underlying mechanism of actionen_US
dc.identifier.affiliationsSchool of Environmental Sciences, Jawaharlal Nehru University, New Delhi-110 067, Delhi, Indiaen_US
dc.identifier.citationRajamani Paulraj, M P Ajith, Gautam Rohit. Impact of Metal and Metal Oxide Nanoparticles on Male Reproductive System: A Comprehensive Review. Indian Journal of Biochemistry & Biophysics. 2022 Nov; 59(11): 1048-1055en_US
dc.identifier.issn0019-5189
dc.identifier.issn0975-1009
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/221593
dc.languageenen_US
dc.publisherCSIR-NIScPRen_US
dc.relation.issuenumber11en_US
dc.relation.volume59en_US
dc.source.urihttps://doi.org/10.56042/ijbb.v59i11.67292en_US
dc.subjectMetal and metal oxide nanoparticlesen_US
dc.subjectmale reproductive systemen_US
dc.subjectspermen_US
dc.subjectreactive oxygen speciesen_US
dc.subjectoxidative stressen_US
dc.titleImpact of Metal and Metal Oxide Nanoparticles on Male Reproductive System: A Comprehensive Reviewen_US
dc.typeJournal Articleen_US
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