Effect of Inula racemosa root extract on cardiac function and oxidative stress against isoproterenol-induced myocardial infarction.

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dc.contributor.authorOjha, Shreesh
dc.contributor.authorBharti, Saurabh
dc.contributor.authorSharma, Ashok K
dc.contributor.authorRani, Neha
dc.contributor.authorBhatia, Jagriti
dc.contributor.authorKumari, Santosh
dc.contributor.authorArya, Dharamvir Singh
dc.date.accessioned2011-11-15T06:36:00Z
dc.date.available2011-11-15T06:36:00Z
dc.date.issued2011-02
dc.description.abstractThe cardioprotective potential of Inula racemosa root hydroalcoholic extract against isoproterenol-induced myocardial infarction was investigated in rats. The rats treated with isoproterenol (85 mg/kg, s.c.) exhibited myocardial infarction, as evidenced by significant (P<0.05) decrease in mean arterial pressure, heart rate, contractility, relaxation along with increased left ventricular end diastolic pressure, as well as decreased endogenous myocardial enzymatic and non-enzymatic antioxidants. Isoproterenol also significantly (P<0.05) induced lipid peroxidation and increased leakage of myocyte injury marker enzymes. Pretreatment with I. racemosa extract (50, 100 or 200 mg/kg per day, p.o.) for 21 consecutive days, followed by isoproterenol injections on days 19th and 20th significantly (P<0.05) improved cardiac function by increasing the heart rate, mean arterial pressure, contractility and relaxation along with decreasing left ventricular end diastolic pressure. Pretreatment with I. racemosa also significantly (P<0.05) restored the reduced form of glutathione and endogenous antioxidant enzymes superoxide dismutase, catalase, glutathione peroxidase from the heart, which were depleted after isoproterenol administration. In addition to restoration of antioxidants, I. racemosa significantly (P<0.05) inhibited lipid peroxidation and prevented the leakage of myocytes specific marker enzymes creatine phosphokinase-MB and lactate dehydrogenase from the heart. Thus, it is concluded that I. racemosa protects heart from isoproterenol-induced myocardial injury by reducing oxidative stress and modulating hemodynamic and ventricular functions of the heart. Present study findings demonstrate the cardioprotective effect of I. racemosa and support the pharmacological relevance of its use and cardioprotection mechanism in ischemic heart disease as well as substantiate its traditional claimen_US
dc.identifier.citationOjha Shreesh, Bharti Saurabh, Sharma Ashok K, Rani Neha, Bhatia Jagriti, Kumari Santosh, Arya Dharamvir Singh. Effect of Inula racemosa root extract on cardiac function and oxidative stress against isoproterenol-induced myocardial infarction. Indian Journal of Biochemistry & Biophysics. 2011 Feb; 48(1): 22-28.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/135296
dc.language.isoenen_US
dc.source.urihttps://nopr.niscair.res.in/bitstream/123456789/11101/1/IJBB%2048%281%29%2022-28.pdfen_US
dc.subjectAntioxidanten_US
dc.subjectCardiac functionen_US
dc.subjectCardioprotective potentialen_US
dc.subjectInula racemosaen_US
dc.subjectIsoproterenolen_US
dc.subjectOxidative stressen_US
dc.subjectPushkarmoolen_US
dc.subjectVentricular functionen_US
dc.subject.meshAnimals
dc.subject.meshCatalase --drug effects
dc.subject.meshCatalase --metabolism
dc.subject.meshCreatine Kinase, MB Form --drug effects
dc.subject.meshCreatine Kinase, MB Form --metabolism
dc.subject.meshGlutathione --drug effects
dc.subject.meshGlutathione --metabolism
dc.subject.meshGlutathione Peroxidase --drug effects
dc.subject.meshGlutathione Peroxidase --metabolism
dc.subject.meshHeart Rate --drug effects
dc.subject.meshHemodynamics --drug effects
dc.subject.meshInula
dc.subject.meshIsoproterenol
dc.subject.meshL-Lactate Dehydrogenase --drug effects
dc.subject.meshL-Lactate Dehydrogenase --metabolism
dc.subject.meshLipid Peroxidation --drug effects
dc.subject.meshMale
dc.subject.meshMyocardial Infarction --chemically induced
dc.subject.meshMyocardial Infarction --drug therapy
dc.subject.meshOxidative Stress --drug effects
dc.subject.meshPhytotherapy --methods
dc.subject.meshPlant Extracts --pharmacology
dc.subject.meshPlant Roots --metabolism
dc.subject.meshRats
dc.subject.meshRats, Wistar
dc.subject.meshSuperoxide Dismutase --drug effects
dc.subject.meshSuperoxide Dismutase --metabolism
dc.subject.meshVentricular Function, Left --drug effects
dc.titleEffect of Inula racemosa root extract on cardiac function and oxidative stress against isoproterenol-induced myocardial infarction.en_US
dc.typeArticleen_US
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