Blood culture positive sepsis and sensitivity pattern in a tertiary care neonatal centre in eastern India

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dc.contributor.authorRath, Souminien_US
dc.contributor.authorPanda, Santosh Kumaren_US
dc.contributor.authorNayak, Manas Kumaren_US
dc.contributor.authorPradhan, Deepti Damayantyen_US
dc.date.accessioned2020-09-24T07:43:15Z
dc.date.available2020-09-24T07:43:15Z
dc.date.issued2019-03
dc.description.abstractBackground: The objective of this study is to evaluate sensitive pattern of causative organisms of neonatal sepsis with its clinical outcome in a tertiary neonatal care unit of eastern India.Methods: This retrospective observational cohort study was done in a tertiary care hospital of Odisha. All the blood culture positive neonatal sepsis cases, excluding neonates with multiple congenital malformations, diagnosed during January 2017 to December 2018 were analysed using descriptive summary statistics.Results: A total of 73 neonatal sepsis cases were diagnosed by BacT/Alert and VITEK-2 blood culture method. Among them, 50 (68%) babies had gram negative sepsis,14 (19%) cases of gram-positive sepsis and nine (13%) cases of fungal sepsis. In present study 38 (52%) cases were early onset sepsis, 38(52 %) babies were term, 55(75%) were male and 44 (60%) babies were out born. Klebsiella pneumonia and Acinetobacter were the most common organism in early onset and late onset sepsis respectively. Among gram negative organism (GNB), 66% were multi drug resistant. A fifty percent of gram-negative organism were sensitive to meropenem and 28% were sensitive to piperacillin/tazobactam. The sensitivity of GNB to colistin, ciprofloxacin, amikacin was 76%, 64% and 56% respectively. The sensitivity of gram-positive organisms to linezolid, vancomycin, teicoplanin and penicillin were 92%, 85%,85% and 20% respectively. Survival rate among culture positive sepsis was 83%.Conclusions: Multi drug organisms are emerging in modern neonatal care practice. Practice of antibiotic stewardship may save the babies from multidrug resistance organism in future.en_US
dc.identifier.affiliationsDepartment of Paediatrics, KIMS hospital, KIIT, University, Odisha, Indiaen_US
dc.identifier.citationRath Soumini, Panda Santosh Kumar, Nayak Manas Kumar, Pradhan Deepti Damayanty. Blood culture positive sepsis and sensitivity pattern in a tertiary care neonatal centre in eastern India. International Journal of Contemporary Pediatrics. 2019 Mar; 6(2): 487-490en_US
dc.identifier.issn2349-3283
dc.identifier.issn2349-3291
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/203962
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber2en_US
dc.relation.volume6en_US
dc.source.urihttps://dx.doi.org/10.18203/2349-3291.ijcp20190686en_US
dc.subjectMultidrug resistanceen_US
dc.subjectNeonateen_US
dc.subjectSepsisen_US
dc.titleBlood culture positive sepsis and sensitivity pattern in a tertiary care neonatal centre in eastern Indiaen_US
dc.typeJournal Articleen_US
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