Comparison of Two Chemotheropy Regimens (CHOP and COP) for Non-Hodgkin's Lymphoma

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dc.contributor.authorSaowanee Chutipongen_US
dc.contributor.authorAnchalee Boonyaritipongen_US
dc.contributor.authorPetch Rawdareeen_US
dc.date.accessioned2011-02-22T09:11:13Z
dc.date.available2011-02-22T09:11:13Z
dc.date.created2010-03-29en_US
dc.date.issued2010-03-29en_US
dc.description.abstractAbstract Comparison of Two Chemotheropy Regimens (CHOP and COP) for Non-Hodgkin's Lymphoma Saowanee      Chutipong                  MD Anchalee       Boonyaritipong         MD Petch              Rawdaree                   MD Department of Medicine, BMA Medical College and Vajira Hospital Objective:  To study efficacy of chemotherapy CHOP and COP in non-Hodgkin's lymphoma (NHL) by median     survival time and mortality rate, Study design: Cohort study. Subjects: Eighty sevent patients of intermediate and high grade NHL who attend in hematology clinic, Department of Medicine, BMA Medical College and Vajira Hospital from January 1985 to March 2000. Methods:  Follow up the patients who were intermediate and high grade NHL treated continuously by CHOP regimen (cyclophosphamide, doxorubicin, vencristine and prednisolone) every month in the first group.  And the second groups were treated continuously by COP regimen (cyclophosphamide, vincristine and prednisolone every month for two years.  Every patient were followed up about 55 months (average). Main outcome measures: Median survival time and crude mortality rate. Results:  Median survival time of CHOP group is 28 months whereas 44 months in COP group but there was no statistically significant difference (p = 0.19).  The crude mortality rate in CHOP group was higher than in COP patients 1.901 time, but there was no statistically significant difference (p = 0.35).  When they were adjust Kaplan-Miere curve of survival by age group and staging there was statistically significant difference, by grading there was no statistically significant difference. Conclusion:  Median survival time and crude mortality rate in this study showed no difference in efficacy of CHOP and COP treatment.  When they were adjust Kaplan-Miere curve of survival by age group and staging there was statistically significant difference, by grading there was no statistically significant difference. Key words:   non-Hodgkin's lymphoma, chemotherapy Vajira Med J 2001 ; 45 : 13 - 20en_US
dc.identifier.citationVajira Medical Journal; Vol. 45 No. 1 January - April 2001; 13-20en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/133067
dc.language.isoen_USen_US
dc.publisherVajira Medical Journalen_US
dc.rightsFaculty of Medicine, Vajira Hospital, University of Bangkok Metropolis, Bangkok, Thailanden_US
dc.source.urihttps://thailand.digitaljournals.org/index.php/VMJ/issue/archiveen_US
dc.source.urihttps://thailand.digitaljournals.org/index.php/VMJ/article/view/2852en_US
dc.titleComparison of Two Chemotheropy Regimens (CHOP and COP) for Non-Hodgkin's Lymphomaen_US
dc.typeOriginal Articlesen_US
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