Comparative bioavailability study of clonazepam after oral administration of two tablet formulations.

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dc.contributor.authorChauhan, B Len_US
dc.contributor.authorSane, S Pen_US
dc.contributor.authorRevankar, S Nen_US
dc.contributor.authorRammamurthy, Len_US
dc.contributor.authorDoshi, Ben_US
dc.contributor.authorBhatt, A Den_US
dc.contributor.authorBhate, V Ren_US
dc.contributor.authorKulkarni, R Den_US
dc.date.accessioned2000-10-24en_US
dc.date.accessioned2009-05-30T19:54:22Z
dc.date.available2000-10-24en_US
dc.date.available2009-05-30T19:54:22Z
dc.date.issued2000-10-24en_US
dc.description.abstractOBJECTIVE: To assess the bioavailability of clonazepam from two brands of 2 mg tablet formulations--Epitril and reference brand. METHODS: A two-way randomised cross-over bioavailability study was carried out in 12 healthy male volunteers. Coded plasma samples were analysed for levels of clonazepam by high performance liquid chromatography (HPLC) method. RESULTS: The mean Cmax, Tmax t1/2 beta and AUC (0-48) for Epitril were: 16.31 +/- 3.07 ng/mL, 1.63 +/- 0.48 h, 46.97 +/- 12.26 h and 207.70 +/- 57.07 ng/ml.h; for reference brand were 19.75 +/- 5.95 ng/mL, 1.42 +/- 0.29 h, 46.88 +/- 11.29 h and 215.70 +/- 50.89 ng/ml.h respectively. These were comparable and the differences were not statistically significant. CONCLUSION: Based on above pharmacokinetic parameters, Epitril was bioequivalent to reference brand.en_US
dc.description.affiliationNovartis India Limited, Churchgate, Mumbai-400 020.en_US
dc.identifier.citationChauhan BL, Sane SP, Revankar SN, Rammamurthy L, Doshi B, Bhatt AD, Bhate VR, Kulkarni RD. Comparative bioavailability study of clonazepam after oral administration of two tablet formulations. Journal of the Association of Physicians of India. 2000 Oct; 48(10): 985-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/87212
dc.language.isoengen_US
dc.source.urihttps://www.japi.orgen_US
dc.subject.meshAdministration, Oralen_US
dc.subject.meshAdulten_US
dc.subject.meshAnalysis of Varianceen_US
dc.subject.meshBiological Availabilityen_US
dc.subject.meshChemistry, Pharmaceuticalen_US
dc.subject.meshChromatography, High Pressure Liquiden_US
dc.subject.meshClonazepam --administration & dosageen_US
dc.subject.meshCross-Over Studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshReference Valuesen_US
dc.subject.meshSensitivity and Specificityen_US
dc.subject.meshTabletsen_US
dc.titleComparative bioavailability study of clonazepam after oral administration of two tablet formulations.en_US
dc.typeClinical Trialen_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
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