The absence of JC virus antigens in Indian children with medulloblastomas.

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dc.contributor.authorVasishta, Rakesh Kumaren_US
dc.contributor.authorPasricha, Neelamen_US
dc.contributor.authorNath, Avindraen_US
dc.contributor.authorSehgal, Shobhaen_US
dc.date.accessioned2009-01-13en_US
dc.date.accessioned2009-05-29T11:59:45Z
dc.date.available2009-01-13en_US
dc.date.available2009-05-29T11:59:45Z
dc.date.issued2009-01-13en_US
dc.description.abstractBACKGROUND: The human polyoma virus, also known as the JC virus (JCV), replicates predominantly in the oligodendrocytes, the myelin producing cells in the central nervous system and results in the fatal demyelinating disease progressive multifocal leukoencephalopathy (PML) especially in immunosuppressed patients with AIDS. Several investigators have also documented the presence of the viral genome and early and late antigens in a variety of brain tumors particularly in medulloblastomas, gliomas and ependymomas. Reports also indicate the presence of JCV in patients with colon cancer. The T antigen of JCV has been postulated to have oncogenic potential as substantiated by animal experiments. Although JCV infects 80% of the population, there are scant epidemiological studies regarding JCV from India. There are also reports of the low prevalence of PML in patients with AIDS from India and Africa. AIM: This study was undertaken to investigate if Indian children with medulloblastomas also show evidence of JCV. METHODS: Twenty-two consecutive cases of medulloblastomas were investigated for the presence of T antigen and agnoprotein of JCV in biopsy specimens by immunohistochemistry. Antibodies to the agnoprotein antigen raised in rabbits and a monoclonal antibody against SV40 T antigen raised in mice that cross-reacts with JCV T antigen were used. RESULTS: Out of 22 patients, 4 had desmoplastic tumors while the rest had classical tumors. All children were below the age of 10. Results indicate that while PML tissues showed consistent immunostaining both with antibody to T antigen and agnoprotein antibody, none of the tumors showed any positive staining for JC viral antigens. CONCLUSION: JCV antigens could not be detected by immunohistochemistry in the tumor tissues of Indian children with medulloblastomas.en_US
dc.description.affiliationDepartment of Immunopathology, Post Graduate Institute of Medical Education and Research, Chandigarh 160 011, UT, India.en_US
dc.identifier.citationVasishta RK, Pasricha N, Nath A, Sehgal S. The absence of JC virus antigens in Indian children with medulloblastomas. Indian Journal of Pathology & Microbiology. 2009 Jan-Mar; 52(1): 42-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/74117
dc.language.isoengen_US
dc.source.urihttps://www.ijpmonline.orgen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntibodies, Monoclonal --diagnostic useen_US
dc.subject.meshAntibodies, Viral --diagnostic useen_US
dc.subject.meshAntigens, Polyomavirus Transforming --analysisen_US
dc.subject.meshBiopsyen_US
dc.subject.meshBrain --pathologyen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshIndiaen_US
dc.subject.meshJC Virus --chemistryen_US
dc.subject.meshMedulloblastoma --virologyen_US
dc.subject.meshMiceen_US
dc.subject.meshRabbitsen_US
dc.subject.meshViral Regulatory and Accessory Proteins --analysisen_US
dc.titleThe absence of JC virus antigens in Indian children with medulloblastomas.en_US
dc.typeCase Reportsen_US
dc.typeJournal Articleen_US
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