Cord blood leptin levels in normal pregnancies, pregnancy induced hypertension and gestational diabetes mellitus.

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dc.contributor.authorSilva, N Yen_US
dc.contributor.authorTennekoon, K Hen_US
dc.contributor.authorSenanayake, Len_US
dc.contributor.authorKarunanayake, E Hen_US
dc.date.accessioned2009-05-28T05:51:32Z
dc.date.available2009-05-28T05:51:32Z
dc.date.issued2008-09-06en_US
dc.descriptionThe Ceylon Medical Journal.en_US
dc.description.abstractOBJECTIVE: To compare cord blood leptin concentrations between normal pregnancy, pregnancy induced hypertension (PIH), and gestational diabetes mellitus (GDM). DESIGN: Cross-sectional study. SETTING: Academic institutes and a tertiary care maternal hospital. METHOD: 48 newborns of normal pregnancies (N=18), pregnancy induced hypertension (N=16), and gestational diabetes mellitus (N=14) were studied. Cord blood samples were collected and newborn anthropometric indices recorded at delivery. Leptin concentrations were measured using an enzyme immunoassay. RESULTS: Cord blood leptin levels were significantly different between the 3 groups (Kruskal-Wallis ANOVA; P=0.0064), and the difference resulted mainly from higher levels in GDM than in PIH [geometric mean (95% CI) for GDM: 10.89 (6.30, 18.84) vs PIH: 3.49 (2.14, 5.69) ng/ml (Dunn's multiple comparison: P<0.01). This pattern persisted even when leptin levels were normalized to the ponderal index (Kruskal-Wallis ANOVA P=0.0035; Dunn's multiple comparison: P<0.01). Leptin levels significantly and positively correlated with the ponderal index in normal pregnancy (Spearman r=0.506, p<0.05) and with birth weight in PIH (r=0.5463, p<0.05). CONCLUSION: In GDM cord blood leptin levels are significantly higher, and a source other than fetal adipocytes appears to contribute to this.en_US
dc.description.affiliationInstitute of Biochemistry, Molecular Biology and Biotechnology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.en_US
dc.identifier.citationSilva NY, Tennekoon KH, Senanayake L, Karunanayake EH. Cord blood leptin levels in normal pregnancies, pregnancy induced hypertension and gestational diabetes mellitus. The Ceylon Medical Journal. 2008 Sep; 53(3): 79-82en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/49150
dc.language.isoengen_US
dc.source.urihttps://www.infolanka.com/CMJhome/en_US
dc.source.urihttps://www.sljol.info/index.php/CMJ/article/view/246/254en_US
dc.subject.meshBirth Weighten_US
dc.subject.meshBody Heighten_US
dc.subject.meshCross-Sectional Studiesen_US
dc.subject.meshDiabetes, Gestational --blooden_US
dc.subject.meshFemaleen_US
dc.subject.meshFetal Blood --chemistryen_US
dc.subject.meshHumansen_US
dc.subject.meshHypertension, Pregnancy-Induced --blooden_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshLeptin --blooden_US
dc.subject.meshPregnancy --blooden_US
dc.titleCord blood leptin levels in normal pregnancies, pregnancy induced hypertension and gestational diabetes mellitus.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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