Transcutaneous oxygen tension and ankle brachial pressure index as predictors of outcome in diabetic foot

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dc.contributor.authorAtri, Ken_US
dc.contributor.authorRizvi, SAAen_US
dc.contributor.authorKhullar, Sen_US
dc.contributor.authorHossain, MMen_US
dc.contributor.authorAhmad, Jen_US
dc.contributor.authorAbidi, SSA.en_US
dc.date.accessioned2023-06-27T06:37:58Z
dc.date.available2023-06-27T06:37:58Z
dc.date.issued2022-07
dc.description.abstractBackground: Diabetic foot ulcer poses a serious threat to patients with Diabetes as the presence of an ulcer further significantly increases the risk of an amputation. Aim and Objectives: The present study was undertaken to assess: Correlation of transcutaneous oxygen tension (TcpO2) and ankle brachial pressure index (ABI) in outcome of diabetic foot and severity of neuropathy by grades. Materials and Methods: About 30 patients of Type 2 Diabetes Mellitus with foot lesions and 30 healthy controls were selected after obtaining informed consent and ethical committee clearance. Subjects were recruited taking into consideration various inclusion and exclusion criteria. The subjects were assessed for the following parameters: Vibration perception, hot, and cold perception along with TcpO2 and ankle brachial pressure index (ABI). The test results were compared within the two groups of cases, that is, Group I: Healed ulcer and Group II-Non-healed ulcer. The results of the two groups were compared with 30 healthy controls also. Results: Males were predominant (66.67%) compared to females (33.33%) in the diabetic foot patients. Severe derangements in the sensory modalities were found as observed by the bilaterally reduced values of vibration perception, hot perception and cold perception tests when diabetic foot patients were compared to controls. The values, however, were not significantly different between the two groups of patients of diabetic foot. The values of TcPO2 and ABI were bilaterally reduced in the cases as compared to controls and amongst the Group I and Group II comparison these values showed a significant difference. A highly significant positive correlation was observed between the TcPO2 and ABI test results in the diabetic foot patients that indicates both are complimentary tests for diabetic foot outcome prediction. Conclusion: Increased duration of diabetes, high value of Hba1c and presence of neuropathy were found to be important risk predictors for diabetic foot. Early and severe derangement of vibration perception indicated early involvement of large nerve fibers. Heat and cold perception is affected late and less severely, indicating late involvement of small nerve fibers in diabetic polyneuropathy. The positive correlation between TcPO2 and ABI indicates both are complementary tests for predicting the outcome of diabetic foot. However, TcPO2 being a better predictor maybe incorporated as a routine screening test for diabetic foot risk and outcome predictor in the diabetic foot clinic.en_US
dc.identifier.affiliationsDepartment of Physiology, Al-Falah School of Medical Science and Research Centre, Dhouj, Haryana, Indiaen_US
dc.identifier.affiliationsDepartment of Physiology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Physiology, ESIC Medical College, Alwar, Rajasthan, Indiaen_US
dc.identifier.affiliationsRajiv Gandhi Centre for Diabetes and Endocrinology, Faculty of Medicine, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Physician and Diabetologist, Diabetes Care Clinic, Aligarh, Uttar Pradesh, Indiaen_US
dc.identifier.citationAtri K, Rizvi SAA, Khullar S, Hossain MM, Ahmad J, Abidi SSA.. Transcutaneous oxygen tension and ankle brachial pressure index as predictors of outcome in diabetic foot. National Journal of Physiology, Pharmacy and Pharmacology. 2022 Jul; 12(7): 962-969en_US
dc.identifier.issn2231-3206
dc.identifier.issn2320-4672
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/217614
dc.languageenen_US
dc.publisherMrs Dipika Charan of MedScience (India) Publicationsen_US
dc.relation.issuenumber7en_US
dc.relation.volume12en_US
dc.source.urihttps://dx.doi.org/10.5455/njppp.2022.12.09347202120122021en_US
dc.subjectAnkle-brachial Pressure Indexen_US
dc.subjectDiabetic Foot Ulceren_US
dc.subjectTranscutaneous Oxygen Tensionen_US
dc.titleTranscutaneous oxygen tension and ankle brachial pressure index as predictors of outcome in diabetic footen_US
dc.typeJournal Articleen_US
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