Serum transcobalamin II levels in patients with malaria infection.

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dc.contributor.authorAreekul, Sen_US
dc.contributor.authorChurdchu, Ken_US
dc.contributor.authorCheeramakara, Cen_US
dc.contributor.authorWilairatana, Pen_US
dc.contributor.authorCharoenlarp, Pen_US
dc.date.accessioned2009-05-27T16:08:08Z
dc.date.available2009-05-27T16:08:08Z
dc.date.issued1995-03-01en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractSerum transcobalamin II (TCII) levels were determined in 56 patients with P. falciparum malaria infection. They were divided into 3 groups: severe (malarial parasite > 5% or patients with cerebral malaria or renal insufficiency), moderate (1-5% infection without complications) and mild (1% infection). Elevated serum TCII values were found only in patients with severe malaria infection. These values correlated directly with parasitemia, blood urea nitrogen and creatinine, but were not correlated with alkaline phosphatase. As 17 patients with azotemia had elevated serum TCII levels while other 3 patients with normal BUN and creatinine concentrations had serum TCII levels within the normal limits. These findings indicated that malarial patients with renal insufficiency had increased serum TCII. A possible mechanism is the reduced TCII-B12 that filtered through the glomeruli due to the reduced renal blood flow with the decreased its uptake by proximal tubular cells resulting in the decreased degradation of TCII by the tubular lysosomal enzymes. Determination of serum TCII level may be used as an indicator of renal function in malarial patients with renal insufficiency.en_US
dc.description.affiliationDepartment of Tropical Radioisotopes, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.en_US
dc.identifier.citationAreekul S, Churdchu K, Cheeramakara C, Wilairatana P, Charoenlarp P. Serum transcobalamin II levels in patients with malaria infection. The Southeast Asian Journal of Tropical Medicine and Public Health. 1995 Mar; 26(1): 46-50en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/34498
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/publication.htmen_US
dc.subject.meshBiological Markersen_US
dc.subject.meshBlood Urea Nitrogenen_US
dc.subject.meshCreatinine --blooden_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshKidney Failure --blooden_US
dc.subject.meshMalaria, Cerebral --blooden_US
dc.subject.meshMalaria, Falciparum --blooden_US
dc.subject.meshMaleen_US
dc.subject.meshParasitemia --blooden_US
dc.subject.meshRegression Analysisen_US
dc.subject.meshSeverity of Illness Indexen_US
dc.subject.meshTranscobalamins --metabolismen_US
dc.titleSerum transcobalamin II levels in patients with malaria infection.en_US
dc.typeJournal Articleen_US
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