Lupus anticoagulant in immune thrombocytopenic purpura.

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dc.contributor.authorDash, Sumitraen_US
dc.contributor.authorMarwaha, R Ken_US
dc.contributor.authorMohanty, Sambiten_US
dc.date.accessioned2004-06-01en_US
dc.date.accessioned2009-05-30T15:45:12Z
dc.date.available2004-06-01en_US
dc.date.available2009-05-30T15:45:12Z
dc.date.issued2004-06-01en_US
dc.description.abstractOBJECTIVE: Antibodies against phospholipid antigens (APA) have been demonstrated in adult idiopathic(immune) thrombocytopenic purpura (ITP), but their clinical and pathogenetic significance has remained elusive. Also there are no such studies available in pediatric ITP cases. In this study, the prevalence and clinical significance of APAs were investigated in pediatric patients with ITP. METHODS: Forty newly diagnosed ITP patients (age 2-13 years) were prospectively studied. They were evaluated for the presence of lupus anticoagulant (LA). RESULTS: Eleven patients (27.5%) were LA positive at the time of diagnosis. No statistically significant differences were found between the LA-positive and LA-negative groups regarding gender, initial platelet counts, or response to methyl prednisolone therapy. After 6 months of follow up, 5 of the 11 LA-positive cases were still positive for LA. The frequency of LA positivity found in this pediatric age group was similar to that reported in adult patients. CONCLUSION: In view of the fact that in adult patients with ITP, the persistent presence of APAs is an important risk factor for the development of antiphospholipid syndrome, the same may also hold true for pediatric ITP patients, and thus 'demands long term follow up for these patients.en_US
dc.description.affiliationDepartment of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. sumitradash2001@yahoo.comen_US
dc.identifier.citationDash S, Marwaha RK, Mohanty S. Lupus anticoagulant in immune thrombocytopenic purpura. Indian Journal of Pediatrics. 2004 Jun; 71(6): 505-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/83917
dc.language.isoengen_US
dc.source.urihttps://medind.nic.in/icb/icbai.shtmlen_US
dc.subject.meshAdolescenten_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIndia --epidemiologyen_US
dc.subject.meshInfanten_US
dc.subject.meshLupus Coagulation Inhibitor --blooden_US
dc.subject.meshMaleen_US
dc.subject.meshPrevalenceen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshPurpura, Thrombocytopenic, Idiopathic --blooden_US
dc.titleLupus anticoagulant in immune thrombocytopenic purpura.en_US
dc.typeJournal Articleen_US
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