The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review

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dc.contributor.authorChanchlani, Roshanen_US
dc.contributor.authorAgrawal, Amiten_US
dc.contributor.authorJanjua, Dalwinderen_US
dc.contributor.authorHafsa, Shaik Nidaen_US
dc.date.accessioned2023-08-25T06:40:00Z
dc.date.available2023-08-25T06:40:00Z
dc.date.issued2023-08
dc.description.abstractBackground: Serotonin receptors 5-HT1B and 5-HT1D in the cerebral arteries are activated by the 5-hydroxytryptophan agonists (triptans) to relieve the discomfort associated with migraines. Even though triptans are often used to treat acute migraines, there is some debate over their effectiveness. Objective: Our systematic review aimed to evaluate the effectiveness of triptans for acute treatment of migraine in young individuals. Methods: Utilizing the databases of Google Scholar, Cochrane Library, and PubMed, a literature search was conducted, and all papers published till July 2022 were included. This systematic review was carried out following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standards. In addition to the Boolean operators AND, OR, and NOT, the following descriptive terms were also used: “Triptans,” “Pediatric Migraine,” “Migraine disorders,” “Headache,” “Children,” and “Adolescent.” Results: A total of 1047 studies were identified, and 25 articles were finally included in the study. 17 of them were RCTs while the remaining were non-randomized trials. Most studies recruited participants aged between 12-17 years. Among 25 studies, 7 reported sumatriptan use, 3 assessed a combination of sumatriptan and naproxen, 4 were on almotriptan, 1 on eletriptan, 6 on rizatriptan, and 4 on zolmitriptan use. Conclusion: We found that rizatriptan (good tolerability profile with a dose of 5 mg) and sumatriptan (nasal spray, 10 mg and 20 mg) had higher efficiency as compared to other triptans. Regardless of type or dose, all triptans are generally well tolerated by patients, but a few adverse effects such as light-headedness (sumatriptan), nasopharyngitis, and, muscular spasms (sumatriptan/ naproxen), somnolence, and dry mouth (rizatriptan), and dizziness (zolmitriptan group) were reported with the triptans.en_US
dc.identifier.affiliationsDepartment of Pediatric Surgery, All India Institute of Medical Sciences, Bhopal, Madhya Pradeshen_US
dc.identifier.affiliationsDepartment of Pediatrics, Gandhi Medical College, Bhopal, Madhya Pradeshen_US
dc.identifier.affiliationsDepartment of Neonatology, Al Jalila Children’s Specialty Hospital, Dubai, United Arab Emiratesen_US
dc.identifier.affiliationsDepartment of Otorhinolaryngology, Rajiv Gandhi University of Health Sciences, Karnataka, India.en_US
dc.identifier.citationChanchlani Roshan, Agrawal Amit, Janjua Dalwinder, Hafsa Shaik Nida. The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review. Indian Pediatrics. 2023 Aug; 60(8): 663-671en_US
dc.identifier.issn0079-6061
dc.identifier.issn0974-7559
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/225455
dc.languageenen_US
dc.publisherIndian Academy of Pediatricsen_US
dc.relation.issuenumber8en_US
dc.relation.volume60en_US
dc.source.urihttps://indianpediatrics.net/aug2023/663.pdfen_US
dc.subjectAdverse effecten_US
dc.subjectManagementen_US
dc.subjectSerotonin-5 HT 1 receptor agonistsen_US
dc.subjectTryptamine.en_US
dc.titleThe Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Reviewen_US
dc.typeJournal Articleen_US
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