Response rate to vaccination against Hepatitis B virus among health care workers at St. Dominic Hospital, Akwatia, Ghana

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dc.contributor.authorAmoakoDuahen_US
dc.contributor.authorNkansah, Adwoa Agyeien_US
dc.contributor.authorEvelyn, Amoakoen_US
dc.contributor.authorMaite, Alfonso Romeroen_US
dc.contributor.authorRafiq, Okineen_US
dc.contributor.authorDuah, Franciscaen_US
dc.date.accessioned2020-09-24T07:21:10Z
dc.date.available2020-09-24T07:21:10Z
dc.date.issued2019-10
dc.description.abstractBackground: Hepatitis B is a major contributor to the burden of infectious diseases worldwide. Many preventive measures havebeen employed, however, active immunization with hepatitis B vaccine remains the single most important hepatitis B preventionmeasure. WHO recommends that all health care workers (HCWs) should be vaccinated against HBV. However, proportions ofindividuals do not respond to the recommended standard three dose of HBV vaccination and remain susceptible to theinfection.Objectives: This study was to assess the response rate to vaccination against HBV among health care workers and todetermine predictors of non-response to HBV vaccine in HCWs. Methods and Materials: A prospective study carried out at theSaint Dominic Hospital, Akwatia, involving 100 HCWs from 29th August, 2018 to 4th June, 2019. All the participants received thestandard protocol of 3 intramuscular injections of HBV vaccine (Engerix B) at 0, 1, and 6 months. Qualitative and quantitativeserum anti-HBs was determined 1-2 months after the last injection in order to detect the responders and non-responders.Results:Majority (54.0%) of the participants were males. The Median age of the study participants was 35 (29, 47) with age range of 20-65 years. Out of the 100 HCWs 90 (90%) were responders and 10 (10%) were non-responders to hepatitis B vaccine. Nonresponders had increased odds of being female, though this was not statistically significant (COR=1.47 (0.42 - 5.17).Conclusion:All HCWs should undergo confirmatory testing of immune response after completion of scheduled standard HBV immunization.This will ensure safety of all HCWs against HBV infection.en_US
dc.identifier.affiliationsSenior Physician Specialist/Gastroenterologist, Korle-Bu Teaching Hospital, P. O. Box 77. Accra, Korle-Bu 5WHO Country Office, Ghanaen_US
dc.identifier.affiliationsConsultant Gatroenterologist, Korle-Bu Teaching Hospital, P. O. Box 77. Accra, Korle-Bu 5WHO Country Office, Ghanaen_US
dc.identifier.affiliationsSt. Dominic Hospital, Akwatia, P. O. Box 59, Akwatia, E/Ren_US
dc.identifier.affiliationsSt. Dominic Hospital, Akwatia, P. O. Box 59, Akwatia, E/Ren_US
dc.identifier.affiliationsDepartment of Medicine, Korle-Bu Teaching Hospital, P. O. Box 77. Accra, Korle-Bu 5WHO Country Office, Ghanaen_US
dc.identifier.citationAmoakoDuah, Nkansah Adwoa Agyei, Evelyn Amoako, Maite Alfonso Romero, Rafiq Okine, Duah Francisca. Response rate to vaccination against Hepatitis B virus among health care workers at St. Dominic Hospital, Akwatia, Ghana. International Journal of Medical and Health Sciences . 2019 Oct; 8(4): 58-62en_US
dc.identifier.issn2277-4494
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/203104
dc.languageenen_US
dc.publisherInternational Journal of Medical and Health Sciencesen_US
dc.relation.issuenumber4en_US
dc.relation.volume8en_US
dc.source.urihttps://www.ijmhs.net/articles/5e022fb875c89.pdfen_US
dc.subjectHealth care workersen_US
dc.subjectImmune responseen_US
dc.subjectHepatitis B vaccineen_US
dc.subjectGhanaen_US
dc.titleResponse rate to vaccination against Hepatitis B virus among health care workers at St. Dominic Hospital, Akwatia, Ghanaen_US
dc.typeJournal Articleen_US
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