Role of in vivo proton MR spectroscopy in the evaluation of adult brain lesions: our preliminary experience.

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dc.contributor.authorKumar, Aen_US
dc.contributor.authorKaushik, Sen_US
dc.contributor.authorTripathi, R Pen_US
dc.contributor.authorKaur, Pen_US
dc.contributor.authorKhushu, Sen_US
dc.date.accessioned2003-12-27en_US
dc.date.accessioned2009-06-03T11:34:01Z
dc.date.available2003-12-27en_US
dc.date.available2009-06-03T11:34:01Z
dc.date.issued2003-12-27en_US
dc.description.abstractCONTEXT: A definite diagnosis and characterization of intracranial mass lesions, based on structural Magnetic Resonance Imaging (MRI) alone may be difficult. In such cases Proton Magnetic Resonance Spectroscopy (1H-MRS) along with other non-invasive techniques represents an advance in the specificity of brain lesion diagnosis. AIMS: The primary aim of this study was to evaluate the extent of the utility of 1H-MRS in adult brain tumors and their differentiation from similar-appearing space-occupying lesions. MATERIAL AND METHODS: MRS studies were performed on 1.5 Tesla whole body MR system using standard imaging head coil. Sixty patients (aged 30-65 years), including 35 males (31-65 years) and 25 females (30-65 years) were studied, along with 25 age-matched healthy volunteers (30-64 years). The Student 't' test was used to statistically analyze the spectroscopic data for significant difference in the metabolite ratios of the lesions from normal brain tissue. RESULTS: The Cho/Cr ratio was significantly raised in low and high-grade glioma and meningioma patients (1.85 +/- 0.36, 3.50 +/- 1.00 and 6.65 +/- 2.83 respectively) (mean +/- standard deviation), as compared with the control group (1.16 +/- 0.18); and NAA/Cr and NAA/Cho ratios were found to be lower than normal values in our study (P<0.01). However, in the non-neoplastic lesions, the Cho/Cr ratios were not statistically significant. The tubercular lesions revealed an average Cho/Cr ratio of 1.24 +/- 0.18, while it was 1.14 +/- 0.07 for infarcts. CONCLUSION: MR Spectroscopy was useful to arrive at a more definitive diagnosis in doubtful intracranial space-occupying lesions with similar morphological imaging patterns.en_US
dc.description.affiliationInstitute of Nuclear Medicine & Allied Sciences, Brig S K Mazumdar Road, Delhi-110054, India.en_US
dc.identifier.citationKumar A, Kaushik S, Tripathi RP, Kaur P, Khushu S. Role of in vivo proton MR spectroscopy in the evaluation of adult brain lesions: our preliminary experience. Neurology India. 2003 Dec; 51(4): 474-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/120974
dc.language.isoengen_US
dc.source.urihttps://neurologyindia.comen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshBrain Neoplasms --diagnosisen_US
dc.subject.meshFemaleen_US
dc.subject.meshGlioma --diagnosisen_US
dc.subject.meshHumansen_US
dc.subject.meshMagnetic Resonance Spectroscopyen_US
dc.subject.meshMaleen_US
dc.subject.meshMeningeal Neoplasms --diagnosisen_US
dc.subject.meshMeningioma --diagnosisen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshProtonsen_US
dc.titleRole of in vivo proton MR spectroscopy in the evaluation of adult brain lesions: our preliminary experience.en_US
dc.typeJournal Articleen_US
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