Predictors of Malnutrition in Children with Cystic Fibrosis

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dc.contributor.authorDhochak, Nitinen_US
dc.contributor.authorJat, Kana Ramen_US
dc.contributor.authorSankar, Jhumaen_US
dc.contributor.authorLodha, Rakeshen_US
dc.contributor.authorKabra, Sushil Ken_US
dc.date.accessioned2020-04-23T07:44:27Z
dc.date.available2020-04-23T07:44:27Z
dc.date.issued2019-10
dc.description.abstractObjective: To determine occurrence of malnutrition in childrenwith cystic fibrosis and identify predictors of malnutrition at time ofenrolment and after 2 years of follow up.Design: Retrospective chart review.Setting: Pediatric chest clinic at a tertiary-care center in northernIndia.Patients: Cystic fibrosis patients enrolled between 2009-2015with at least 3 years follow-up.Procedure: Weight and height were noted at enrolment, and after1 year and 2 years of follow-up. Clinical details, medications, andpulmonary exacerbations during second year were recorded.Main outcome measure: Occurrence of malnutrition i.e. weightfor age Z-score < -2.Results: 61 medical records were reviewed. Occurrence ofmalnutrition at baseline, and 1- and 2-year follow-up was 65.5%,54.1% and 57.3%, respectively. Weight for age Z-score atenrolment significantly correlated with time to diagnosis fromonset r=0.015, P=0.029). Weight for age Z-score at 2-year follow-up was significantly associated with steatorrhea (P=0.03),increased frequency of stools (P<0.01) and pulmonaryexacerbation (P=0.03) during second year. Linear regressionshowed significant association between weight for age Z-score at2 years with steatorrhea and pulmonary exacerbations [r=-0.795(-1.527, -0.062)] and [r=-0.261 (-0.493, -0.028)]. Pulmonaryexacerbations during second and third year had significantcorrelation with weight for age Z-score at the beginning ofrespective years (r = -0.219, P=0.015).Conclusion: Occurrence of malnutrition is high in children withcystic fibrosis in this region, with uncontrolled fat malabsorptionand recurrent respiratory infections being significant risk factors.en_US
dc.identifier.affiliationsDeepartment of Pediatrics, All India Institute of Medical Sciences, New Delhi, Indiaen_US
dc.identifier.citationDhochak Nitin, Jat Kana Ram, Sankar Jhuma, Lodha Rakesh, Kabra Sushil K. Predictors of Malnutrition in Children with Cystic Fibrosis. Indian Pediatrics. 2019 Oct; 56(10): 825-830en_US
dc.identifier.issn0974-7559
dc.identifier.issn0019-6061
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/199399
dc.languageenen_US
dc.publisherIndian Academy of Pediatricsen_US
dc.relation.issuenumber10en_US
dc.relation.volume56en_US
dc.source.urihttps://www.indianpediatrics.net/oct2019/825.pdfen_US
dc.subjectFat malabsorptionen_US
dc.subjectNutritionen_US
dc.subjectPulmonaryexacerbation.en_US
dc.titlePredictors of Malnutrition in Children with Cystic Fibrosisen_US
dc.typeJournal Articleen_US
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