Evaluation of use of Volume Conductivity Scatter Parameters as Early Indicator of Sepsis in Elderly Patients: A Hospital Based Case Control Study

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dc.contributor.authorAgarwal, Ruchien_US
dc.contributor.authorYadav, Deepikaen_US
dc.contributor.authorSindhu, Anjalien_US
dc.contributor.authorRana, Parveenen_US
dc.contributor.authorGathwal, Monikaen_US
dc.contributor.authorKaur, Swaranen_US
dc.date.accessioned2020-09-24T07:10:32Z
dc.date.available2020-09-24T07:10:32Z
dc.date.issued2019-08
dc.description.abstractIntroduction: Sepsis in elderly patients is a critical clinicalissue due to high rates of morbidity and mortality. The modernage cell counters precisely measure volume, size and internalstructure of the cell thereby assessing increase in volumeand cytoplasmic granularity of leukocytes as seen in casesof sepsis. The present study was done to evaluate the useof Volume Conductivity Scatter (VCS) parameters as earlyindicators of sepsis in elderly patients and to overcome theshortcomings of blood culture by using a more precise VCStechnology to assess morphologic changes in cell populationsin sepsis.Material and Method: The study included 51 patients abovethe age of 50 years which were divided into 2 groups Group1, patients with localised infection (n= 39) and Group 2 withsystemic infection (n=12). Group 3 included 30 controlswithout any signs of infection and with total leucocyte countand differential counts within normal limits. Coulter LH 750cellular analysis system was used.Result: Significant increase in both mean neutrophil volume(MNV) and mean monocyte volume (MMV) was reportedamong the patients with sepsis as compared to localizedinfections or control. With a cut off of 145 and 170 for MNVand MMV respectively, a sensitivity of 96% and 91.4% wasobtained in predicting sepsis.Conclusion: Both MNV and MMV have the potential to beused as early indicators of acute bacterial infections.en_US
dc.identifier.affiliationsAssociate Professor, Department of Pathology, Bhagat Phool Singh Government Medical College for Women, Khanpur Kalan, Sonepat (Haryana)en_US
dc.identifier.affiliationsIntern, Bhagat Phool Singh Government Medical College for Women, Khanpur Kalan, Sonepat (Haryana)en_US
dc.identifier.affiliationsPost Graduate Student, Department of Pathology, Bhagat Phool Singh Government Medical College for Women, Khanpur Kalan, Sonepat (Haryana)en_US
dc.identifier.affiliationsAssociate Professor, Department of Pathology, Bhagat Phool Singh Government Medical College for Women, Khanpur Kalan, Sonepat (Haryana)en_US
dc.identifier.affiliationsAssociate Professor, Department of Pathology, Bhagat Phool Singh Government Medical College for Women, Khanpur Kalan, Sonepat (Haryana)en_US
dc.identifier.affiliationsProfessor and Head, Department of Pathology, Bhagat Phool Singh Government Medical College for Women, Khanpur Kalan, Sonepat (Haryana), Indiaen_US
dc.identifier.citationAgarwal Ruchi, Yadav Deepika, Sindhu Anjali, Rana Parveen, Gathwal Monika, Kaur Swaran. Evaluation of use of Volume Conductivity Scatter Parameters as Early Indicator of Sepsis in Elderly Patients: A Hospital Based Case Control Study. International Journal of Contemporary Medical Research . 2019 Aug; 6(8): h4-h7en_US
dc.identifier.issn2393-915X
dc.identifier.issn2454-7379
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/202539
dc.languageenen_US
dc.publisherInternational Society for Contemporary Medical Researchen_US
dc.relation.issuenumber8en_US
dc.relation.volume6en_US
dc.source.urihttps://dx.doi.org/10.21276/ijcmr.2019.6.8.38en_US
dc.subjectSepsisen_US
dc.subjectVolume Conductivity Scatteren_US
dc.subjectMean Neutrophil Volumeen_US
dc.subjectMean Monocyte Volume.en_US
dc.titleEvaluation of use of Volume Conductivity Scatter Parameters as Early Indicator of Sepsis in Elderly Patients: A Hospital Based Case Control Studyen_US
dc.typeJournal Articleen_US
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