Comparison of Streptococcus pneumoniae serotypes causing acute otitis media & invasive disease in young children in the Czech Republic.

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dc.contributor.authorPrymula, Ren_US
dc.contributor.authorMotlova, Jen_US
dc.contributor.authorKriz, Pen_US
dc.date.accessioned2004-05-03en_US
dc.date.accessioned2009-05-27T07:11:23Z
dc.date.available2004-05-03en_US
dc.date.available2009-05-27T07:11:23Z
dc.date.issued2004-05-03en_US
dc.description.abstractBACKGROUND & OBJECTIVES: The availability of a type-specific pneumococcal vaccine for children is a worldwide problem. It is necessary to study the serotypes prevalent in a country before introducing a type-specific vaccine. The objective of the present study was to analyse the prevalence of Streptococcus pneumoniae serotypes in children suffering from acute otitis media or invasive pneumococcal disease and to compare a coverage of serotypes by individual pneumococcal vaccines. METHODS: Children suffering from acute otitis media and invasive pneumococcal disease were analysed in the Czech Republic from October 1999 to November 2000. Serotyping was performed by the quellung technique using antisera from Statens Serum Institute (Denmark). RESULTS: The most frequent serotypes in patients with acute otitis media were 3, 19F, 23F, 14, 9V, 1, 6B, 11A and 28F. Vaccine coverage for the identified serotypes in acute otitis media patients was 52.1 per cent for the 7-valent vaccine, 57.8 per cent for the 9-valent vaccine and 75.7 per cent for the 11-valent form of the vaccine. In 108 patients with invasive pneumococcal disease, the most frequent serotypes were 6B, 9V, 14, 19F, 3 and 23F. Vaccine coverage for the identified serotypes in patients with invasive pneumococcal disease was 62 per cent for the 7-valent vaccine, 66.4 per cent for the 9-valent vaccine and 77.5 per cent for the 11-valent form of the vaccine. INTERPRETATION & CONCLUSION: Vaccine coverage for the identified serotypes for the 11-valent pneumococcal vaccine was better than the other two vaccines.en_US
dc.description.affiliationPurkyne Military Medical Academy, Hradec Kralove, Prague, Czech Republic.en_US
dc.identifier.citationPrymula R, Motlova J, Kriz P. Comparison of Streptococcus pneumoniae serotypes causing acute otitis media & invasive disease in young children in the Czech Republic. Indian Journal of Medical Research. 2004 May; 119 Suppl(): 168-70en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/19676
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAcute Diseaseen_US
dc.subject.meshCzech Republic --epidemiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshInfanten_US
dc.subject.meshOtitis Media --microbiologyen_US
dc.subject.meshPneumococcal Vaccines --administration & dosageen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshStreptococcal Infections --microbiologyen_US
dc.subject.meshStreptococcus pneumoniae --classificationen_US
dc.titleComparison of Streptococcus pneumoniae serotypes causing acute otitis media & invasive disease in young children in the Czech Republic.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeMulticenter Studyen_US
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