Clinico-laboratory profile of central nervous system infection by scrub typhus at a tertiary care hospital

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dc.contributor.authorJha, Ruchien_US
dc.contributor.authorJaiswal, Anil Kumaren_US
dc.date.accessioned2020-09-24T07:43:13Z
dc.date.available2020-09-24T07:43:13Z
dc.date.issued2019-03
dc.description.abstractBackground: Scrub typhus is an emerging epidemic in India. Its course can be complicated by involvement of Respiratory system, cardiovascular system, gastrointestinal system and central nervous system. Central nervous system involvement can lead to major morbidity and mortality.Methods: It is an observational study conducted in the Department of Pediatrics, Patna Medical College and Hospital, Patna from January 2016 to August 2018.' All cases of AES who were serologically proven to be due to scrub typhus were clinically examined, signs and symptoms were noted, and complete blood counts were done. Lumbar puncture was done, and CSF was sent for analysis of cells, sugar and protein, IgM for scrub typhus in CSF, gram staining and CSF culture.Results: Seventy-eight cases were tested positive for scrub typhus. Incidence of scrub typhus among AES cases was 19.4% in the study. Among cases of Scrub typhus, a male predominance and sex ratio was 1.68. Age at presentation ranged from 2 months to 12 years with a mean age of 7.28 years. Most of the cases were seen in the months of September and October with a mini peak in the month of March. Fever and Altered consciousness were present in all the cases. Among laboratory investigations, thrombocytopenia was the most common feature followed by raised Transaminases. CSF Analysis shows mildly increased cell count with lymphocytic predominance and presence of few polymorphs, sugar mildly decreased, and protein mildly raised.Conclusions: Scrub typhus is an important causative agent of AES in the Eastern parts of India. It should be suspected in cases which present as AES with symptoms of hepatosplenomegaly, thrombocytopenia, and elevated liver enzymes in addition to dengue encephalitis which forms its close differential.en_US
dc.identifier.affiliationsDepartment of Pediatrics, Patna Medical College and Hospital, Patna, Bihar, Indiaen_US
dc.identifier.citationJha Ruchi, Jaiswal Anil Kumar. Clinico-laboratory profile of central nervous system infection by scrub typhus at a tertiary care hospital. International Journal of Contemporary Pediatrics. 2019 Mar; 6(2): 375-379en_US
dc.identifier.issn2349-3283
dc.identifier.issn2349-3291
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/203938
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber2en_US
dc.relation.volume6en_US
dc.source.urihttps://dx.doi.org/10.18203/2349-3291.ijcp20190020en_US
dc.subjectCentral nervous system infectionen_US
dc.subjectCSFen_US
dc.subjectScrub typhusen_US
dc.subjectThrombocytopeniaen_US
dc.titleClinico-laboratory profile of central nervous system infection by scrub typhus at a tertiary care hospitalen_US
dc.typeJournal Articleen_US
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