”TAM”ing of the shrew-challenges in the diagnosis of Neonatal leukemia with Down's syndrome -A case report with literature review

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dc.contributor.authorManohar, Sen_US
dc.contributor.authorJayakumar, N.en_US
dc.date.accessioned2023-08-10T07:32:56Z
dc.date.available2023-08-10T07:32:56Z
dc.date.issued2022-09
dc.description.abstractThe latest WHO (2017) classification describes the hematological abnormalities of Down's syndrome as a separate entity under 'Myeloid proliferations associated with Down's syndrome'. It includes Transient Abnormal Myelopoiesis and Myeloid leukemia of Down's syndrome. Here we report a case of a 3 days old neonate with Down's syndrome, presenting with a leukemic blood picture. The baby had icterus, fever and hepatosplenomagaly. Peripheral blood showed megakaryoblasts and giant platelets. A diagnosis of transient abnormal myelopoiesis was made by confirming with karyotyping and immunophenotyping. We attempt to address all the diagnostic challenges faced by a clinician and pathologist same, upon encountering such a case,by following an algorithmic approach. The mandatory need for follow up and cytogenetic studies in identifying high risk cases that will become myeloid leukemia of Down's syndrome are stressed. Our case also throws light upon the significance of identification of GATA1 mutation in diagnosing and prognostication of such cases.en_US
dc.identifier.affiliationsDepartment of Pathology, Government Sivagangai Medical College, Sivagangai, Tamil Nadu, Indiaen_US
dc.identifier.citationManohar S, Jayakumar N.. ”TAM”ing of the shrew-challenges in the diagnosis of Neonatal leukemia with Down's syndrome -A case report with literature review. Indian Journal of Pathology & Microbiology. 2022 Sept; 65(3): 699-701en_US
dc.identifier.issn0377-4929
dc.identifier.issn0974-5130
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/223328
dc.languageenen_US
dc.publisherWolters Kluwer - Medknowen_US
dc.relation.issuenumber3en_US
dc.relation.volume65en_US
dc.source.urihttps://doi.org/10.4103/ijpm.ijpm_731_21en_US
dc.subjectAcute megakaryoblastic leukemiaen_US
dc.subjectDownâ's syndromeen_US
dc.subjectGATA1en_US
dc.subjectnewbornen_US
dc.title”TAM”ing of the shrew-challenges in the diagnosis of Neonatal leukemia with Down's syndrome -A case report with literature reviewen_US
dc.typeJournal Articleen_US
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