Methaemoglobin analysis in acute dapsone poisoning.
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Date
2012-01
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Abstract
A case of acute dapsone poisoning in a 21 year-old female is being reported. Dapsone is well known for inducing serious methaemoglobinaemia and haemolysis in overdose situations. Estimating the methaemoglobin (MetHb) concentration in the blood is critical for effective management. Quantification of MetHb by spectrophotometer is generally advocated along with complete haematological and liver function investigations.
In this paper, we highlight the importance of quantifying MetHb by spectrophotometer, which is very simple, and demonstrates high sensitivity
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Keywords
Dapsone overdose, Methaemoglobin (MetHb), Spectrophotometry, Liver function tests
Citation
Vijayakumar P G, Rajendiran C, Malathi D, Suganya A. Methaemoglobin analysis in acute dapsone poisoning. Journal of the Indian Society of Toxicology. 2012 Jan; 8(1): 20-22.