Expression of the neurotrophin receptors Trk A and Trk B in adult human astrocytoma and glioblastoma.

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dc.contributor.authorWadhwa, Shashien_US
dc.contributor.authorNag, Tapas Cen_US
dc.contributor.authorJindal, Anupamen_US
dc.contributor.authorKushwaha, Rahulen_US
dc.contributor.authorMahapatra, Ashok Ken_US
dc.contributor.authorSarkar, Chitraen_US
dc.date.accessioned2003-03-25en_US
dc.date.accessioned2009-06-01T14:19:29Z
dc.date.available2003-03-25en_US
dc.date.available2009-06-01T14:19:29Z
dc.date.issued2003-03-25en_US
dc.description.abstractNeurotrophins and their receptors of the Trk family play a critical role in proliferation, differentiation and survival of the developing neurons. There are reports on their expression in neoplasms too, namely, the primitive neuroectodermal tumours of childhood, and in adult astrocytic gliomas. The involvement of Trk receptors in tumour pathogenesis, if any, is not known. With this end in view, the present study has examined 10 tumour biopsy samples (identified as astrocytoma, pilocytic astrocytoma and glioblastoma) and peritumoral brain tissue of adult patients, for the presence of Trk A and Trk B receptors, by immunohistochemistry. The nature of the tumour samples was also confirmed by their immunoreactivity (IR) to glial fibrillary acidic protein. In the peritumoral brain tissue, only neurons showed IR for Trk A and Trk B. On the contrary, in the tumour sections, the IR to both receptors was localized in the vast majority of glia and capillary endothelium. There was an obvious pattern of IR in these gliomas: high levels of IR were present in the low-grade (type I and II) astrocytoma; whereas in the advanced malignant forms (WHO grade IV giant cell glioblastoma and glioblastoma multiforme) the IR was very weak. These findings suggest that Trk A and Trk B are involved in tumour pathogenesis, especially in the early stage, and may respond to signals that elicit glial proliferation, and thus contribute to progression towards malignancy.en_US
dc.description.affiliationDepartment of Anatomy, CN Center, All India Institute of Medical Sciences, New Delhi 110 029, India. shashiwadhwa@hotmail.comen_US
dc.identifier.citationWadhwa S, Nag TC, Jindal A, Kushwaha R, Mahapatra AK, Sarkar C. Expression of the neurotrophin receptors Trk A and Trk B in adult human astrocytoma and glioblastoma. Journal of Biosciences. 2003 Mar; 28(2): 181-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/110748
dc.language.isoengen_US
dc.source.urihttps://www.ias.ac.in/jbiosci/index.htmlen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAstrocytoma --metabolismen_US
dc.subject.meshFemaleen_US
dc.subject.meshGlioblastoma --metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshReceptor, trkA --metabolismen_US
dc.subject.meshReceptor, trkB --metabolismen_US
dc.titleExpression of the neurotrophin receptors Trk A and Trk B in adult human astrocytoma and glioblastoma.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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