Lewis antigens on newborn red cells.

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dc.contributor.authorKijkornpan, Sen_US
dc.contributor.authorSuebsaeng, Cen_US
dc.contributor.authorChiewsilp, Pen_US
dc.date.accessioned2009-05-27T19:01:10Z
dc.date.available2009-05-27T19:01:10Z
dc.date.issued2000-03-24en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractThis study aimed to screen for Lewis antigens in Thai newborns. Although, these antigens are known to be weak or absent on the red cells of newborns, we encountered a case of a Le(a+) newborn baby when testing with monoclonal antibody and human anti-Le(a). Such a finding led us to conduct this study to explore further evidence of Lewis antigens in Thai newborn red cells. A total of 197 cord blood samples were tested with monoclonal anti-Le(a) and anti-Le(b). (Bioclone, Ortho Diagnostic Systems, USA). The tests were performed according to the manufacturer's recommendations. The results revealed that none of the cord red cells in this study group possessed Lewis antigens. This study showed that Lewis antigens were absent or were so extremely weak on the red cells of these newborn infants that they could not be demonstrated despite the use of potent monoclonal antibodies. However, further study should be done by using more cord blood samples, a more sensitive technique or even more potent antisera.en_US
dc.description.affiliationDepartment of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.en_US
dc.identifier.citationKijkornpan S, Suebsaeng C, Chiewsilp P. Lewis antigens on newborn red cells. Journal of the Medical Association of Thailand. 2000 Mar; 83 Suppl 1(): S46-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/40308
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAntigens, CD15 --analysisen_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshErythrocytes --immunologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshFetal Blooden_US
dc.subject.meshHumansen_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshMaleen_US
dc.subject.meshSensitivity and Specificityen_US
dc.subject.meshThailanden_US
dc.titleLewis antigens on newborn red cells.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
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